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Biomedical subjects

J D Douglas

Publications and source records attributed to J D Douglas.

34 records · Page 2Linked to original sources
PubMed1984

Chromosome aberrations in divers.

The incidence of chromosome gain and loss and chromosomal aberrations has been measured in 48-h lymphocyte cultures of divers and control subjects as part of an overall research program to identify possible long-term health hazards associated with commercial diving. When the two diving groups, air divers (n = 77) and helium-oxygen divers (n = 76), are compared with two control groups, oil rig workers (n = 75) and nonoil industry controls (n = 52), 3.9% (6 out of 153) had an unusually high number of structural aberrations in a small portion of the dividing lymphocytes. Similar damage was not found in controls. The remaining 147 divers had a similar low incidence of chromosomal aberrations to the two control groups. The factors responsible for this phenomenon are not known, but several aspects of diving can effectively be ruled out. These are: direct effects of pressure, breathing mixture, radiographic exposure, and viral infection. The causative agent must be acting locally on lymphocytes after their last maturation division. Further studies are continuing on this topic in an effort to identify the causative factor or factors.

Air↗
PubMed1970

Melioidosis in imported non-human primates.

In 1969, five cases of melioidosis in three separate outbreaks were diagnosed in nonhuman primates in the United States. In the first outbreak, two stump-tailed macaque monkeys (Macaca arctoides) developed signs of the disease approximately 6 months after purchase. A third animal, a chimpanzee (Pan troglodytes), probably acquired its infection from one of these monkeys. Two other unrelated cases involving a pig-tailed monkey (Macaca nemestrina) and a rhesus monkey (Macaca mulatta) were diagnosed. These monkeys had been imported 3 years and 6 months, respectively, prior to the recognized onset of their disease. These cases represent the first known occurrences of spontaneous melioidosis in nonhuman primates in the United States.

Animals↗