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J D Connor

Publications and source records attributed to J D Connor.

159 records · Page 9Linked to original sources
PubMedDate not supplied

Levodopa pharmacokinetics. Alterations after benserazide, a decarboxylase inhibitor.

Plasma levodopa decay curves appeared to be triexponential up to 6 hr after single intravenous injections of levodopa in rats, rabbits, and dogs. After pretreatment of each of these three species with benserazide (Ro-4-4602), a decarboxylase inhibitor, plasma levodopa concentrations declined biexponentially. Administration of benserazide decreased both total plasma clearance and apparent volume of distribution of levodopa, but did not change the rate constant of the terminal phase of the plasma levodopa decay curve. Thus, decarboxylase inhibition failed to alter the plasma half-life of levodopa.

Animals↗
PubMedDate not supplied

Brain iron: location and function.

This review has a focus on the distribution and function of iron in human brain and appropriate animal models. Data are presented on the consequences of abnormalities of iron status with regard to neural development, neurotransmitter metabolism, and cognition.

Animals↗