Biomedical subjects
Publications and source records attributed to J D Connolly.
From fresh leaves of Alberta magna two new iridoids and a known cyclopentene dialdehyde have been identified. One of the new compounds has the less-common irido-lactone structure and has an enolic hydrogen on C-4. Two of the compounds show short term mosquito-repellent effects.
A novel derivative of sucrose, beta-(3,6-di-O-feruloyl)-fructofuranosyl-alpha-(2,3,4,6-tetra-O-ac etyl)- glucopyranoside, was isolated from the wood of Bhesa paniculata. Its structure was determined by a combination of 2D 1H-1H and 1H-13C correlation NMR spectroscopy. The known compounds, glycerol 1-9',12'-octadecadienoate, beta-sitosterol, (+/-)-pinoresinol, methyl 3,4-dihydroxybenzoate, 4-hydroxy-3-methoxybenzoic acid, anofinic acid and 2-(1'-methylethenyl)-benzofuran-5-carboxylic acid were also isolated.
Two new oleanolic acid saponins were isolated from the leaves and roots of Beta vulgaris. Both contained the unusual feature of a 3,4 seco-glycopyranosyl moiety. Their structures were established by a combination of 2D NMR experiments and of Californium plasma desorption mass spectrometry.
Two new chromone glycosides, schumanniofiosides A and B have been isolated from the root bark of Schumanniophyton magnificum and their structures shown to be 2-methyl-5,7-dihydroxychromone 5-O-beta-D-glucopyranoside and 2-methyl-5,7-dihydroxychromone 7-O-beta-D-glucopyranosyl-(1----2)-apiofuranoside, respectively. The structures were elucidated by a combination of spectral data and chemical degradation.
Explore the source record for details and available documents.
The effects of premedication with the anticholinergic drugs atropine, hyoscine and glycopyrronium when administered by oral and i.m. routes have been evaluated in patients undergoing minor surgery and compared with a placebo using a double-dummy double-blind technique. Although the mouths of those patients who received adequate doses of anticholinergic drugs were dry, subjectively and observed, as compared with those who received a placebo, the overall course of anaesthesia did not appear to be different. Of the three drugs atropine seemed to be absorbed best following oral administration. Equally effective oral and i.m. doses of atropine were considered to be 2.0 and 1.0 mg respectively; of hyoscine 1.0 and 0.25--0.5 mg. The appropriate dose of glycopyrronium was 0.2 mg i.m. The routine use of anticholinergic drugs in preanaesthetic medication in minor surgery appears to be unnecessary.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A structure/activity study of selected limonoids from two plant families (Meliaceae and Rutaceae) of the Rutales order against the murine P-388 lymphocytic leukemia system was undertaken. The presence of both a 19 leads to 28 lactol and a 14,15 beta-epoxide group was found especially important for pronounced inhibition of the PS in vitro cell line. Substitution of an A-ring alpha,beta-unsaturated ketone (3-oxo-1-ene) for the lactol led to diminished activity, while reduction of the olefin caused complete loss of activity. At the dose levels employed, even very good PS in vitro inhibition was not translated into PS in vivo antineoplastic effects.
The stem bark of Teclea ouabanguiensis has yielded six triterpenoids, two of which are new. The known compounds were identified spectroscopically as 7-deacetylazadirone (2), 7-deacetylproceranone (3), tecleanin, (4), and lupeol. The novel compounds include the tetranortriterpenoids, 7-deacetoxy-7-oxoazadirone (1), and ouabanginone (5). The biogenetic significance of the presence of these limonoids in T. ouabanguienis is discussed.