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Biomedical subjects

J D Christensen

Publications and source records attributed to J D Christensen.

At least 73 records · Page 4Linked to original sources
PubMed1982

Disulfiram treatment of three patients with nickel dermatitis.

Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg more than than twice a day readily cleared the eczema in three patients with severe and long-standing nickel contact dermatitis.

Aged↗
PubMed1982

Lack of effect of opiates on release of vasopressin from isolated rat neurohypophysis.

Electrical stimulation of rat neurohypophysis in vitro results in a 150-fold increase in release of vasopressin. Incubation of the isolated lobes with endogenous opiates (Met-enkephalin, Leu-enkephalin, beta-endorphin), morphine or naloxone did not change the evoked release of vasopressin significantly. The results obtained do not confirm the hypothesis that endogenous opiates inhibit the release of vasopressin from this preparation.

Animals↗
PubMed1982

Demodex folliculorum hominis (Simon): incidence in a normomaterial and in patients under systemic treatment with erythromycin or glucocorticoid.

A study was made of 20 cilia and sebum from 20 nasal follicles from each of 86 persons. In a normomaterial aged 20-30 years. Demodex folliculorum was present in the nasal follicles in 25% and in the cilia in 29% of the subjects. This is consistent with the very high incidence we found 10 years ago. Systemic erythromycin treatment did not erradicate the mite, but the incidence decreased in both regions. Systemic glucocorticoid treatment lowered the incidence in the nasal region, whereas the incidence increased in the ciliary region.

Adult↗
PubMed1981

Frequency of cataract in atopic dermatitis.

Atopic cataract (AC) has been reported to occur as many as one patient in every five with atopic dermatitis (AD). The lenticular opacities may rapidly lead to blindness. To establish whether in Denmark screening of AD patients is justified especially for AC, 51 such patients underwent ophthalmological examination. None of them were found to have AC. Although the study does not exclude a certain incidence of AC, there is nothing to indicate that routine ophthalmological examination of patients with AD is required.

Adolescent↗
PubMed1981

Human leukocyte mobilization and morphology in nickel contact allergy using a skin chamber technique.

An improved skin chamber technique has been devised and used for quantitative evaluation of the leukocyte mobilization rate (LMR). The method was applied in 10 nickel-hypersensitive patients exposed to nickel sulphate. Each patient served as his own control and for additional control purpose, 5 healthy individuals without nickel hypersensitivity were studied. The kinetics of the mobilized leukocytes were followed over a 48-hour period. After an initial lag phase of 2-4 hours, maximum migration was observed from the 24th to the 48th hour, with a wide interindividual variability in the number of mobilized cells at the time of maximum LMR response. The median cumulative leukocyte count was 1.412 x 10(6) leukocytes/cm2/48 h. In the same period a statistically significant increase in the basophils for all the nickel allergic patients was observed. In 8 out of 10 patients a statistically significant effect upon the lymphocytes could be demonstrated. Six of these 8 patients had an increased lymphocyte mobilization. Throughout the period the neutrophil granulocytes were the dominant cell type, although the number decreased as the number of basophils and lymphocytes increased. The chamber technique is a valuable means for quantitative evaluation of leukocyte mobilization and morphology in skin exudates during exposure to an allergen in delayed hypersensitivity reactions.

Adult↗
PubMed1980

Hormonal polypeptides and amine metabolites in small cell carcinoma of the lung, with special reference to stage and subtypes.

To elucidate the ectopic hormonal pattern in patients with small cell carcinoma of the lung, plasma ACTH, serum calcitonin, serum gastrin, plasma glucagon, serum insulin, plasma secretin, plasma VIP, serum growth hormone, serum hCG/LH, the total of serum hCG and hCG-beta-subunit,serum alpha-subunit, serum human placental lactogen, urine ADH, urine 5-HIAA, urine VMA, urine HVA, and urine hCG-LH were measured prior to therapy in 75 patients. Twenty-two patients (29%) had elevated plasma ACTH, and 18 of these had concomitant increased values of corticosteroid in a 24-hour urine sample. Forty-eight patients (64%) were found to have elevated serum calcitonin, and one-third of the patients were diagnosed as having the ectopic ADH syndrome. Serum gastrin concentrations were increased in 20% of the patients, but the elevations were marginal in almost all cases. None of the remaining substances was found to be significantly elevated. Concentrations of plasma ACTH, serum calcitonin, and urine ADH were not found to be correlated with the stage of the disease, and no correlation of these substances with the histological subtypes of small cell carcinoma was disclosed.

Adrenocorticotropic Hormone↗