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Biomedical subjects

J D Cash

Publications and source records attributed to J D Cash.

At least 109 records · Page 6Linked to original sources

Serum fibrin-fibrinogen degradation products associated with postoperative pulmonary embolus and venous thrombosis.

A total of 76 "high-risk" surgical patients were studied for evidence of venous thromboembolic disease. Episodes of deep vein thrombosis and of pulmonary embolism were related to changes in blood levels of fibrin degradation products (F.D.P.). When diagnosed either by ordinary clinical means or by venography and isotope scanning significantly raised F.D.P. levels were found in all cases. Serum F.D.P. estimations are unlikely to help in detecting deep vein thrombosis, but may prove valuable in diagnosing pulmonary embolism.

Adult↗

Fibrinolytic response to moderate exercise in young male diabetics and non-diabetics.

The euglobulin lysis time was measured in 25 young male insulin-dependent diabetics and 25 age- and sex-matched healthy controls before and after a standardized moderate treadmill exercise procedure. There was a statistically significant mean shorter resting euglobulin lysis time in the diabetic group but their ability to respond to the exercise procedure was significantly impaired. It is suggested that this impaired fibrinolytic reactivity may be related to the diminished vaso-active reactivity previously reported in young diabetics.

Adult↗

Serum fibrin degradation products throughout normal pregnancy.

Fibrin/fibrinogen degradation products in the serum of 169 healthy pregnant and 43 healthy non-pregnant subjects of a similar age group showed a significant increase throughout pregnancy, the highest levels being obtained in the third trimester. There was no correlation with plasma fibrinogen levels or euglobulin lysis times. Though these changes may be due to other alterations in pregnancy not primarily associated with fibrinolysis, it is possible that actual fibrinolysis is not decreased in late pregnancy, as has been previously asssumed.

Adult↗