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Biomedical subjects

J D Brown

Publications and source records attributed to J D Brown.

At least 91 records · Page 5Linked to original sources
PubMed1991

Efficacy trial of a parenteral gonococcal pilus vaccine in men.

A randomized, placebo-controlled, double-blind efficacy trial of a purified gonococcal pilus vaccine composed of a single pilus type was tested in 3123 men and 127 women volunteers. Either 100 micrograms of vaccine or a placebo was given intradermally on day 1 and day 14. Each group was evenly matched with respect to age, sex, prior history of a sexually transmitted disease, sexual exposure during the study and attrition from the study. None of the women volunteers acquired gonorrhoea during the trial. In the male volunteers, 108 vaccine and 102 placebo recipients acquired gonorrhoea 15 days or later after the initial immunization. Vaccines developed a sustained ELISA antibody response to homologous and heterologous pili, but the latter titres were approximately 40% as high as the homologous pilus antibody rises. There were, however, no increases in inhibition of attachment antibody (IEA) titres. Local antibodies (semen) against homologous and heterologous strains were also elicited (ELISA). The vaccine was safe and did not alter the clinical expression of disease. This gonococcal pilus vaccine composed of a single pilus type failed to protect men against gonococcal urethritis.

Adult↗
PubMed1991

Staying fit and staying well: physical fitness as a moderator of life stress.

Previous research suggests that physical fitness moderates the adverse effects of stressful life events. However, a reliance on self-reports of fitness and health may limit the validity of prior investigations. The present research tested the stress-buffering effect of fitness with subjective and objective indicators of exercise, fitness, and physical well-being. For self-reports of health, both self-reports of exercise and objective measures of fitness showed the buffering effect; however, only objective fitness levels buffered stress when visits to a health facility were considered. Additional evidence indicated that this effect was largely independent of measures of psychological distress. Implications for understanding the link between fitness, stress, and health status are discussed.

Affect↗
PubMed1991

Group therapy in a forensic setting.

Mentally ill offenders are especially difficult patients to rehabilitate. Although group therapy is a universal method of treating these patients, their ability to benefit from group therapy has not been proven. The authors studied a group of patients held on Warrants of the Lieutenant Governor to assess their personality characteristics and their ability to develop group dynamics which are beneficial in other patient populations. The findings were that forensic patients have personality characteristics which preclude the development of these therapeutic dynamics.

Activities of Daily Living↗
PubMed1991

Television viewing and adolescents' sexual behavior.

Over the past two decades the sexual content on television has increased in frequency and explicitness but has seldom included depiction of the use of contraceptives. Concurrently, the age of initiation of heterosexual intercourse has decreased and the number of teenaged pregnancies has remained high. Are these trends related? This survey of 391 adolescents found that those who chose heavier diets of sexy television shows were more likely than those who viewed a smaller proportion of sexual content on television to have had sexual intercourse. This relationship held regardless of perceived peer encouragement to engage in sex and across race and gender groups. While causal direction is not clear from these data, the relationship suggests that either sexual activity results in increased interest in sexual content in the media and/or that viewing such content leads to sexual activity. In either case, the finding points to the need for further research and increased discussion and portrayal of the use of contraceptives on television.

Adolescent↗
PubMed1991

The influence of three mass media campaigns on variables related to adolescent cigarette smoking: results of a field experiment.

BACKGROUND: This paper reports findings from a field experiment that evaluated mass media campaigns designed to prevent cigarette smoking by adolescents. METHODS: The campaigns featured radio and television messages on expected consequences of smoking and a component to stimulate personal encouragement of peers not to smoke. Six Standard Metropolitan Statistical Areas in the Southeast United States received campaigns and four served as controls. Adolescents and mothers provided pretest and posttest data in their homes. RESULTS AND CONCLUSIONS: The radio campaign had a modest influence on the expected consequences of smoking and friend approval of smoking, the more expensive campaigns involving television were not more effective than those with radio alone, the peer-involvement component was not effective, and any potential smoking effects could not be detected.

Adolescent↗
PubMed1990

Television and adolescent sexuality.

Existing studies of the sexual content of television programming and advertising and the effects of this content on adolescent viewers are reviewed. Content studies show that the frequency of sexual references have increased in the past decade and are increasingly explicit. Studies of the effects of this content, while scarce, suggest that adolescents who rely heavily on television for information about sexuality will have high standards of female beauty and will believe that premarital and extramarital intercourse with multiple partners is acceptable. They are unlikely to learn about the need for contraceptives as a form of protection against pregnancy or disease. Suggestions for future research and trends in television programming policies are explored.

Adolescent↗
PubMed1990

Avascular necrosis of the hip in a man with HIV infection.

The development of an osteonecrotic (avascular necrosis) hip joint in a patient with symptomatic CDC Stage 1V C2 disease is reported. The diagnosis was aided by radiological assessment and confirmed by radioisotope bone scan. This case serves as yet another musculoskeletal manifestation in association with HIV infection.

Adult↗
PubMed1990

A validity problem in measuring exposure to mass media campaigns.

Recognition of radio and television messages included in three mass media campaigns designed to keep adolescents from starting to smoke cigarettes was measured in six treatment and four control cities (Standard Metropolitan Statistical Areas) in the southeastern United States. The telephone survey of 574 randomly selected adolescents found high recognition of campaign messages even in the areas where the campaigns had not been broadcast. Campaign messages that differed significantly from other anti-smoking messages were less likely to be falsely recognized. These results reinforce the need to include true control groups in mass media evaluations and to construct distinctive messages if exposure is an important aspect of campaign evaluation.

Adolescent↗
PubMed1989

A study of the relation between intraocular pressure and aqueous humor flow in the pigment dispersion syndrome.

Forty subjects with pigment dispersion syndrome with and without intraocular pressure (IOP) elevation were compared with 40 age-matched controls. Intraocular pressure, resistance to outflow, and the rate of flow of aqueous humor were compared. Eyes with higher IOP and higher resistance to outflow were found to have a normal rate of aqueous flow. The results are interpreted as demonstrating that moderate and chronic elevation of IOP in the adult human eye does not induce a chronic compensatory reduction of aqueous humor flow.

Adult↗
PubMed1989

Dependency, self-criticism, and depressive attributional style.

Dependency and self-criticism have been proposed as independent factors in depression. Investigated whether depressive individuals characterized by dependency and self-criticism, respectively, differ with regard to internality of causal attributions for negative events. Sixty psychiatric outpatients completed the Depressive Experiences Questionnaire, the Beck Depression Inventory, the semantic differential, and the Attributional Style Questionnaire. Dependency and self-criticism correlated positively with internality and with each other (p less than .0001). Findings did not support the specificity of dependency and self-criticism as subtypes of depression.

Adult↗
PubMed1989

The cost of good fortune: when positive life events produce negative health consequences.

Previous research regarding the effects of positive life events on physical health has been inconclusive. We tested the hypothesis that positive life events have a detrimental effect on health only among people with negative self-views. This prediction derives from an identity disruption model of stress, which holds that an accumulation of life events that are inconsistent with the self-concept leads to physical illness. To test the hypothesis, we conducted two prospective studies in which positive life events and self-esteem were used to predict the development of illness over time. In accordance with predictions, both studies showed that desirable life changes were associated with increases in illness only among subjects with low self-esteem; among subjects with high self-esteem, positive life events were linked to better health. Implications for understanding the manner in which life events affect health are considered.

Adaptation, Psychological↗
PubMed1988

Three mass media campaigns to prevent adolescent cigarette smoking.

This article describes behavioral science theory and formative research used to develop television and radio campaigns for preventing the initiation of cigarette smoking among adolescents. It also presents the content and form of the messages, the plans, and the costs for national implementation of the campaigns.

Adolescent↗
PubMed1988

Attributions for negative life events and depression: the role of perceived control.

Although perceptions of control occupied a central role in the development of learned helplessness theory, recent helplessness research has not considered controllability judgments when relating attributions to depression. Supporting the importance of this construct, the research discussed in this article found evidence that judgments of control interact with other attributions in predicting depression. Specifically, in a prospective study of stress and well-being in adolescence, internal, stable, and global attributions for negative events attributed to uncontrollable causes were found to be positively related to increases in depression (as predicted by the reformulated helplessness theory), but internal and global attributions for negative events attributed to controllable causes were found to be inversely related to increases in depression. The discussion considers the implications of the findings for understanding the nature of the relation between attributions for naturally occurring life events and depression.

Adaptation, Psychological↗
PubMed1988

Exercise as a buffer of life stress: a prospective study of adolescent health.

The hypothesis that physical exercise provides benefits to individuals under periods of life stress has rarely been subject to empirical verification. This article presents the results of a longitudinal study of stress and well-being in adolescence in which the ability of exercise to buffer stress-induced deteriorations in physical health was examined. In accordance with predictions, prospective analyses revealed that the negative impact of stressful life events on health declined as exercise levels increased. These findings suggest that exercise may be a valuable resource for combating life stress. Discussion centers on possible mediating mechanisms and on the practical implications of the results.

Adolescent↗
PubMed1988

Relapse of osteoporosis circumscripta as a lytic ring after treatment of Paget's disease with intravenous 3-amino-1-hydroxypropylidene-1,1-bisphosphonate.

Two patients with osteoporosis circumscripta of the skull are presented who have each been treated with a 3-month course of intravenous infusions of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) (total dose of 185 and 375 mg), which in both cases was associated with rapid and dramatic remineralization of the porotic bone and marked clinical and biochemical remission. However, osteolytic disease reappeared (after 9 and 18 months, respectively) in both cases as an osteolytic ring showing high uptake of radiolabelled bisphosphonate on bone scan, in formerly unaffected bone just distal to the original leading edge of osteolysis. Further treatment was associated with healing of these new lesions. These cases suggest that the diseased osteoclasts entering previously normal bone are protected against the drug probably because normal bone matrix takes up relatively little APD, and that APD taken up by diseased bone behind this front confers long-term resistance to further resorption. In assessing treatment strategies with bisphosphonates for Paget's disease, the response at the leading edge of osteoporosis circumscripta may be particularly informative.

Adult↗
PubMed1987

Critical illness polyneuropathy. A complication of sepsis and multiple organ failure.

Nineteen patients developed polyneuropathy complicating critical illness. They had been admitted to a critical care unit following intubation for cardiac or pulmonary disease and had developed sepsis and multiple organ failure. Approximately one month following intubation, failure to wean from the ventilator and limb weakness prompted neurological referral. Examination disclosed weakness and wasting of muscles and impaired tendon reflexes in most, but not all, patients. Electrophysiological studies in 17 patients revealed attenuated compound muscle and sensory nerve action potential amplitudes and widespread denervation on needle electromyography. Autopsy in 9 patients who died of their critical illness revealed widespread primary axonal degeneration of motor and sensory fibres, with extensive denervation atrophy of limb and respiratory muscles. Survivors recovered from the polyneuropathy three to six months following discharge. Seventeen of the patients were segregated by electrophysiological criteria into mild (8) and severe (9) polyneuropathy categories. An analysis of these two groups failed to reveal putative metabolic, drug, nutritional or toxic factors that might be responsible for the polyneuropathy. Our studies suggest that the mechanism may be a fundamental defect, still unknown, which causes dysfunction of all organ systems in this syndrome.

Adult↗
PubMed1987

Analysis of latex agglutination test for Clostridium difficile toxin A (D-1) and differentiation between C difficile toxins A and B and latex reactive protein.

Virulent toxigenic and avirulent non-toxigenic strains of Clostridium difficile gave a positive result in the latex agglutination test (LAT) for C difficile toxin A (D-1). Similar concentrations of latex agglutinating antigen were produced by these strains in vivo. Positive reactions were also given by C sporogenes, proteolytic C botulinum Types A, B, and A/F, and Bacteroides assaccharolyticus. The latex agglutinating antigen was denatured by boiling for 10 minutes, but not by heating at 56 degrees C for 30 minutes. The reaction was abolished by incubation of test material with crude C difficile antitoxin but not with other clostridial antitoxins or specific antitoxin to C difficile toxin A. The latex agglutinating antigen present in C difficile eluted between 0.39% and 0.47% M sodium chloride, and that produced by the other clostridia, between 0.35% and 0.43% M sodium chloride by fast protein liquid chromatography. The latex agglutinating antigen of C difficile was neither cytotoxic nor mouse lethal and was distinct from toxin A and toxin B. In the analysis of faecal specimens from patients with diarrhoea the latex agglutination test correlated better with the presence of C difficile than with toxin B and detected both toxigenic and non-toxigenic strains. The latex agglutination test should only be used in the laboratory as an alternative to culture for C difficile and not as a method for the detection of C difficile toxins.

Animals↗