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Biomedical subjects

J D Bessman

Publications and source records attributed to J D Bessman.

45 records · Page 3Linked to original sources
PubMed1980

Heterogeneity of red cell volume: quantitation, clinical correlations, and possible mechanisms.

To permit quantitative study of red cell volume heterogeneity, the coefficient of variation (CV) of erythrocyte volume was determined in blood samples from 868 subjects, including normal individuals and those with various hematologic disorders. In groups of subjects with various hemoglobinopathies, CV increased above normal in parallel with the presence and degree of anemia. However, all subjects with iron, folate, or vitamin B12 deficiency showed marked increase in CV (anisocytosis): increased CV accompanied even early iron deficiency not yet associated anemia or microcytosis. Effects of other conditions on CV also were studied.

Anemia↗
PubMed1979

Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor.

The coefficient of variation (CV) of red cell size, as measured by electronic red cell sizing (erythrography), was less than 14.0% in 20 normal subjects. In 22 of 25 patients with beta-thalassemia minor and microcytosis (mean corpuscular volume [MCV] less than 70 fl), CV was less than 14.0%; in the other 3, CV was 14.0%--14.9%. In 53 patients with iron deficiency anemia and MCV less than 70 fl, CV always was greater than 14.0%. In 7 patients with alpha-thalassemia minor and MCV less than 70 fl, CV was less than 14.0% in all 7. Among patients with microcytosis, erythrography appears to be an excellent technique for rapidly distinguishing between iron deficiency and alpha or beta thalassemia minor.

Anemia, Hypochromic↗
PubMed1977

Microcytic polycythemia. Frequency of nonthalassemic causes.

A high RBC count combined with a low mean volume generally is attributed to thalassemia minor, either alpha or beta, or to polycythemia vera with iron deficiency. Among 330 patients with a mean corpuscular volume (MCV) less than 70 cumu, 35 had increased RBC counts. Of these, 26 had thalassemia minor and four had polycythemia vera. Five had secondary polycythemia (four from hypoxia, one from hypernephroma) with incidental iron deficiency. In the four of these patients given iron, the RBC count remained above normal and the MCV rose to normal. The RBC size distribution curves reliably distinguished between thalassemia minor and polycythemia with iron deficiency.

Anemia, Hypochromic↗
PubMed1975

Erythrocyte volume distribution in normal and abnormal subjects.

Size-frequency distribution curves of erythrocytes were generated with the Coulter Counter in 73 normal subjects and patients. Mean corpuscular volume (MCV) determined by routine calculation and MCV determined by size-frequency distribution were similar in all normal subjects and in patients with a single population of erythrocytes. Some patients with iron-deficiency anemia, folate deficiency, and vitamin B12 deficiency had two discrete erythrocyte populations. Some patients with microcytic anemia were shown to have a population of normocytes in addition to the predominant microcytic population. Reticulocytes and normocytes were identified in two patients recovering from macrocytic anemia. Transfused blood was identified as a separate population in a patient with microcytic anemia. In cases with two erythrocyte populations, the MCV of the principal population, as determined from size-distribution curves, differed from the MCV of the entire erythrocyte pool, as was determined by routine methods. Analysis of sequential erythrocyte size distributions in patients under treatment demonstrated the dynamics of erythrocyte subpopulations. Anisocytosis was quantified and shown to be associated frequently with hospitalized patients.

Adenocarcinoma↗
PubMedDate not supplied

Nondiscrete heterogeneity of human blood cells. 1. Volume heterogeneity as a reflection of the quality of erythropoiesis.

Coefficient of variation (C.V.) of red cell volume is inversely proportional to red cell mass in hemoglobinopathies and thalassemias. Even a subject with markedly reduced red cell survival and abnormal hemoglobin had a normal C.V. associated with normal hemoglobin level. In contrast are patients with nutritional deficiency, who have increased C.V. whether or not there is anemia, and patients with hypoplastic anemia, who have normal to near-normal C.V. independent of anemia.

Analysis of Variance↗