Biomedical subjects
J D Bernhard
Publications and source records attributed to J D Bernhard.
Phantom itch, pseudophantom itch, and senile pruritus.
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A review of two controlled multicenter trials comparing 0.05% halobetasol propionate ointment to its vehicle in the treatment of chronic eczematous dermatoses.
The efficacy and safety of 0.05% halobetasol propionate ointment were evaluated in patients with chronic atopic or other eczematous dermatoses in two vehicle-controlled, double-blind studies: a paired-comparison study in 124 patients (study A) and a parallel-group study in 100 patients (study B). In study A, patients applied both treatments twice daily for 2 weeks and were evaluated by investigators on days 0, 7, and 14 with 0 to 3 severity scales and by self-assessment with two 5-step end-of-treatment rating scales. In study B, patients applied treatments twice daily for 2 weeks, and investigators made evaluations on days 0, 3, 7, and 14 with 0 to 6 scales and also made a 5-step end-of-treatment physician's global assessment. In study A, both severity scores and patient ratings favored halobetasol propionate significantly on days 7 (p less than or equal to 0.0013) and 14 (p less than 0.0001); in study B, severity scores on days 3 (p less than or equal to 0.045, pruritus, erythema, and overall lesion severity), 7, and 14 (p less than 0.001, all comparisons) also favored halobetasol propionate significantly, and global assessments showed complete resolution or marked improvement for 83% of patients using halobetasol propionate versus 28% of those using vehicle (p less than 0.0001). No instances of systemic effects or skin atrophy were reported in either study. We conclude that 0.05% halobetasol propionate ointment is highly effective and well tolerated in the treatment of the conditions studied, with the rapid action and high degree of clearing associated with superpotent corticosteroid formulations.
Facial and eyelid psoriasis after cyclosporin withdrawal.
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Macular amyloidosis, notalgia paresthetica and pruritus: three sides of the same coin?
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Pruritus: advances in treatment.
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Itching in the nineties. International Symposium on Itch: basic and clinical aspects, Stockholm, Sweden, May 17-19, 1990.
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Antihistamine update.
Antihistamines are a diverse group of drugs, each possessing the ability to inhibit various actions of histamine. Because they act principally through competitive inhibition of the histamine receptor, they are helpful as a means of preventing rather than reversing these actions. As a result of a resurgence of interest in antihistamine therapy during the past decade, a new class of H1 blockers, clinically devoid of sedative and anticholinergic effects, has evolved. Thus, the choice of antihistamine can now be based on the side effects profile as well as the clinical profile. As we continue to develop a better understanding of these newer agents, we will be able to select more rationally the antihistaminic agent most appropriate to the specific disorder. Used judiciously, the antihistamines available today have a broad application of therapeutic uses, with few significant side effects.
Prophylaxis of steroid-induced purpura.
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My organ is more important than your organ.
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Perimenstrual nonvesicular dermatitis herpetiformis.
A case of nonvesicular dermatitis herpetiformis with clear-cut perimenstrual exacerbations is described and differentiated from autoimmune progesterone dermatitis.
Auspitz sign is not sensitive or specific for psoriasis.
The Auspitz sign refers to the appearance of small bleeding points after successive layers of scale have been removed from the surface of psoriatic papules or plaques. In this study the Auspitz sign was present in only 41 of 234 patients with psoriasis. Furthermore, small bleeding points could be produced when scale was forcibly removed from several nonpsoriatic, scaling disorders, including Darier's disease and actinic keratoses. The frequent absence of the Auspitz sign in psoriasis indicates a lack of sensitivity, whereas its occurrence in other diseases indicates a lack of specificity.
Nocturnal wakening caused by pruritus: organic or psychogenic?
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Incarceration for excoriation.
A thirty-six-year-old man experienced acute, severe, generalized pruritus. His scratching was erroneously interpreted as lewd and indecent behavior. He was arrested. Results of the history and physical examination led to the diagnosis of fiberglass dermatitis, which prompted a dismissal of the charges. Although many societies have looked askance at persons with certain skin diseases (such as leprosy) and at scratching in public since at least biblical times, we are not aware of any prior reports of incarceration for excoriation.
Nonrashes. 6. Telepathic pruritus.
We report the case of a paranoid schizophrenic man who suffered from the delusion that two other men used mental telepathy to make him itch over a period of thirteen years. To our knowledge, this is the first report of "telepathic pruritus."
Nonrashes. 5. Atmoknesis: pruritus provoked by contact with air.
Atmoknesis, itching provoked by open exposure of the skin to air after undressing, is a common and distressing symptom. It occurs in many patients with psoriasis and atopic dermatitis, and in elderly patients with aquagenic pruritus. It also occurs in some patients with underlying systemic causes of generalized pruritus, such as hepatobiliary disease. It does not seem to be an important feature of certain other pruritic skin diseases such as dermatitis herpetiformis and bullous pemphigoid.