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Biomedical subjects

J D Anderson

Publications and source records attributed to J D Anderson.

At least 181 records · Page 10Linked to original sources
PubMed1974

A reappraisal of the antibacterial action of cotrimoxazole in vitro.

The in-vitro action of the sulphamethoxazole/trimethoprim combination (cotrimoxazole) against coliforms, Proteus spp, and Staphylococcus aureus was re-examined. In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to the trimethoprim component. After addition to urine the combination was only bacteriostatic against most coliforms and Proteus spp over six hours. Further clinical trials are needed to determine the circumstances under which cotrimoxazole is superior to either trimethoprim or sulphonamides against some infections, particularly of the urinary tract.

Bacteriological Techniques↗
PubMed1974

Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection.

Co-trimoxazole was found to have a predominantly bacteriostatic effect upon 28 urinary isolates of Enterobacteriaceae in nutrient broth and was never bactericidal in artificially infected urine. The components of co-trimoxazole were tested individually and trimethoprim was found to be at least as effective as co-trimoxazole in nutrient broth and in urine. Trimethoprim alone produced some bactericidal effect in urine but this was antagonized by sulphamethoxazole. Laboratory tests for evaluating these drugs may give a misleading impression of their activity in vivo. Further clinical comparisons should therefore be made between trimethoprim and cotrimoxazole to determine when trimethoprim should be used in preference to the combination.

Culture Media↗