Search PubMed⌕ Search

Biomedical subjects

J Cukier

Publications and source records attributed to J Cukier.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Endoscopic section of the band for urinary retention following aponeurotic supporting of the neck of the bladder].

The authors report on 15 cases of severe dysuria following the formation of an aponeurotic support for the neck of the bladder leading to more or less complete vesicle retention. An endoscopic section through the entire thickness of the band was performed in all patients via an incision in the neck of the bladder. The band was identified in all cases. Vesical retention disappeared in 13 of 15 cases and was noticeably reduced in the other two. Perfect continence was maintained in 11 of these patients. The 4 others presented with slight problems of continence consisting in discrete leaks at night in three cases and in a few leaks when standing up or changing position in one. No vesicovaginal fistula was noted. The authors review the literature on the occasion of their work.

Adult↗
PubMed1990

[Chemotherapy in advanced transitional cell carcinoma of the urinary tract. Phase II trial of a combination of doxorubicin and cisplatin].

Between January 1, 1983 and December 31, 1984, 18 patients with advanced transitional cell carcinoma of the urothelium were treated in a Phase II trial with doxorubicin 45 mg/sqm plus cisplatin 90/mg/sqm/day every four weeks. 17 patients were evaluable for response. There were: 4 partial responses (24% of response objective effects, 95% confidence limits are 15% and 33%) and 13 failures. The median survival was 18.5 months for responders and 10 months for non responders.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[5-year treatment results of urethral stenosis using internal urethrotomy in adults].

The authors reviewed the records of 69 patients with a mean age of 51 years treated for single (81%) or multiple (19%) urethral strictures, in whom the first operation to be performed was endoscopic internal urethrotomy with a follow-up of at least 5 years. The mean follow-up was 71 months. The actuarial rate of good results was 27.2 +/- 11% at 5 years. The success rate of repeated internal urethrotomy was satisfactory, but was not evaluated with the same follow-up (62.5% after the first repeat urethrotomy with a mean follow-up of 13 months).

Adolescent↗
PubMed1990

[Stenosis of the urethra in children. Long-term results of surgical treatment].

Thirty-six urethral strictures were treated between 1977 and 1984. Three strictures were considered to be congenital, eleven were traumatic and twenty-two were iatrogenic. The authors performed twenty five internal urethrotomies, twelve resection-sutures of the urethra and eleven urethroplasties including eight patch grafts with a pedicle derived from scrotal or penile skin, a tubed pedicle scrotal skin flap, one Jurascek urethroplasty and one Leveuf urethroplasty. Internal urethrotomy only gave 50% good results and is now reserved for short strictures less than one centimetre. Of resection-suture is an excellent operation which should be reserved for strictures less than two centimetres: it gave 84% of good results. One of the various types of pedicle cutaneous urethroplasty is certainly the best operation to treat long strictures: it gave more than 90% of good results in the present series.

Adolescent↗
PubMed1990

[Relationships between posterior urethral valves, vesico-renal reflux and renal dysplasia].

Children with valves of the posterior urethra show asymmetric involvement of the upper urinary system with a nonfunctional kidney in 10 to 15% of cases. In a study of 12 nephrectomy patients and 14 reflux patients, the authors reached the conclusion that valvular obstruction, vesico-renal reflux and dysplasia are coexisting anomalies with little relationship between each other.

Humans↗
PubMed1989

Suction lipoplasty: biohazardous aerosols and exhaust mist--the clouded issue.

With the increased popularity of suction lipoplasty procedures, attention has been focused on their safety. One significant concern involves the rotary vane aspirators used to provide the suction required for the procedure. A series of experiments was carried out to determine whether aerosols are produced during the use of a rotary vane aspirator, since aerosols are known to be hazardous under appropriate conditions. Using a viable strain of Pseudomonas aeruginosa, we challenged the system through the suction port, and the exhaust from the aspirator was then cultured in a particle sampler. Results indicate that viable pathogens are released from the exhaust in physiologically significant particles capable of penetrating to the level of the alveolus in the normal human lung. These infectious particles were produced for 3 hours after the initial challenge. When an appropriate filtration device was attached to the aspirator outflow, the aspirator pump and environment were protected. In the absence of an appropriate filtration device, the aerosolized particles may constitute a hazard to patients or medical workers in the vicinity of the aspirator.

Aerosols↗
PubMed1989

[Adjuvant chemotherapy using adriamycin and cisplatin in infiltrating cancer of the bladder. Prospective study of 49 cases].

Between January 1981 and March 1988, we prospectively treated 49 patients with infiltrating bladder cancer (Stages B2, C and D1 of the classification of Marshall or pT3-T4, No/N+ of the UICC classification) by adjuvant combination chemotherapy with Adriamycin and Cisplatin. Chemotherapy started 4 to 8 weeks after radical surgery with total prostatocystectomy in males or anterior pelvectomy in females associated in all cases with bilateral ilio-obturator pelvic lymph node dissection. With a mean follow up of 34 months (3 to 85 months) 32 patients are still alive and disease free (17/23 stage B2, 8/15 stage C, and 7/11 stage D1). The crude disease free survival is 76%, 49% and 25% for stages B2, C and D1 respectively. These results seem better than those reported with radical surgery alone and encourage the adoption of adjuvant chemotherapy to improve survival in patients with infiltrating bladder cancer.

Adult↗
PubMed1989

[Superficial bladder tumors. Results of preventive treatment of recurrence by intravesical instillation of BCG].

Two-thirds of newly diagnosed bladder tumors are superficial transitional cell carcinomas. Local relapses occur in more than 2/3 of the patients after transurethral resection of the initial tumor, with a risk of muscle invasion in 1/3 of them. A retrospective study of 100 consecutive patients was performed to assess the role of intravesical BCG-therapy as a prophylaxis against the recurrence of superficial bladder cancer; the treatment protocol is described. Eighty-two patients had previously had recurrent tumors and 18 were given BCG directly because they had multiple, large, high grade or widespread tumors. Seventy patients (70 p. 100) tolerated the treatment well, but 6 experienced serious complications (3 systemic BCG infections and 3 bladder contractures). Of the 18 patients given BCG after their first tumor, 12 (66 p. 100) are tumor-free with a mean follow-up of 13 months. Of the 82 patients with previous recurrent tumors, 52 (63 p. 100) were improved by the treatment. Of the 100 patients, twelve tumors became muscle invasive and required more aggressive intervention. Intravesical BCG is effective in preventing recurrences of superficial bladder cancer. However, the side effects and the risk of muscle invasion require close monitoring.

Administration, Intravesical↗
PubMed1989

[Tumors of the upper excretory urinary tract. A homogeneous series of 108 patients].

In their study of a homogeneous series of 108 patients operated for a transitional cell tumor of the upper urinary tract, the authors emphasize the following points: --every third tumor has several foci, and it is very difficult to make a complete inventory of all tumoral foci before surgery; --the great majority of these tumors are unilateral. Bilateral recurrence following radical unilateral excision is quite exceptional; --low-grade superficial tumors virtually never invade the lymph nodes, and their prognosis is excellent as a rule; --grade III carcinomas area almost always infiltrating and present high risks of lymph node invasion. Lymph node involvement means that the evolution will be lethal in all cases. None of the patients having invaded lymph nodes survived; --metastases appear soon, usually within the first 24 months, but mainly between the 6th and 12th months following surgery; --20% of the patients in this series died of metastases; --the actuarial survival rate after 5 years is 68%.

Adult↗
PubMed1989

[Value of extracorporeal shockwave lithotripsy in the treatment of urinary lithiasis in children].

We report our experience with extracorporeal lithotripsy (Dornier HM3) in a series of 26 children with a mean age of 11.6 years, treated for 3 1/2 years. 12 children (46%) had a previous history of calculi and 7 (27%) had already undergone surgery on the same side. Treatment requires two transducer investigations before lithotripsy. With the exception of minor modifications the technique is the same as in the adult. Three (9.7%) postlithotripsy complications were noted, requiring 2 drainage procedures to be carried out on the urinary tract. At 3 months, the success rate (no residual calculi on the plain abdominal film) was 60.7%. This study confirms the efficacy of lithotripsy in the treatment of urinary lithiasis in children.

Adolescent↗
PubMed1989

[Extracorporeal shockwave lithotripsy in children].

Upper urinary tract lithiasis is a rare condition in children in comparison to its incidence in the adult population. The distribution of lithiasis in children has been reported to be 56% for idiopathic lithiasis, 20% for metabolic lithiasis, and 25% for lithiasis associated with uropathy. Extracorporeal shock wave lithotripsy (ESWL) has become the treatment of choice for upper urinary tract calculi in the adult patient as well as in children after minor changes and complementary material had permitted the utilization of the Dornier HM-3 lithotripter in these small patients. The reported 3-month success rates range from 47% to 83%, according to the number of patients or kidneys free from calculi. The series reported in the literature have a mean of about 60% completely stone-free kidneys evidenced on the X-ray of the abdomen without preparation at 3 months. Its indications and results are comparable with those of ESWL in the adult. However, the long-term results have as yet not been evaluated and, to date, its hypothetical effects on renal growth or arterial pressure have not yet been elucidated.

Adolescent↗
PubMed1989

[Anomaly of the pyelo-ureteral junction and antenatal ultrasonic diagnosis].

Over a period of five years, 40 cases of anomaly of the pyelo-ureteral junction were diagnosed ante-natally which subsequently required surgical intervention during the first year of life. The indication for the therapy was based on the degree of obstruction (IVU, DTPA scanning, Whitaker test), the thickness of the renal parenchyma (IVU, ultrasound) and, to a lesser extent, on calyceal dilatation. After a period of follow up ranging from 3 to 48 months (mean 16.8 months), good results were noted in 37 cases, there were two permeable junctions with poorly functioning kidneys and one obstruction which was successfully reoperated. These results suggest that intervention is preferable to surveillance at varying intervals for an undetermined period, where the risk of a sudden exacerbation is always possible.

Diagnostic Imaging↗
PubMed1988

[Lithiasis in horseshoe kidney in children. Apropos of 6 cases].

In a 6 cases report of stones developed in horseshoe kidney in children, from 25 months old to 14 years old, diagnosis and surgical problems are analysed. Another urological malformations have to be researched mainly vesico renal reflux and pyelo ureteric junction obstruction. Diagnosis is usually made when stones give complications where septic obstruction is not rare and can be severe in children. Pre and intra-operative sonography can currently do the stone localisation. Surgical management of stones developed in horseshoe kidney seems to be done still by open surgery because new techniques as Eswl or percutaneous lithotripsy can be difficult to perform or dangerous in children on this malformation. Number of operations can often be higher than in adults, to do both treatment of the stone and associated malformation as PUJ obstruction, mainly if there are infected and septic complications.

Adolescent↗
PubMed1988

[Surgical correction of intermittent vesico-ureteral reflux without radiologically detectable reflux].

On the basis of a series of 62 children with no radiological evidence of reflux but with an abnormality of a ureterovesical implantation similar to that seen in children with radiologically detected reflux, the authors attempt to show that under certain precise conditions (presence of cortico-papillary renal lesions, recurrent episodes of acute pyelonephritis, even in the absence of renal lesions), the absence of radiologically detectable reflux is not sufficient to confirm the primary nature of pyelonephritis. The sub-mucosal course of the ureters was found to be short in all of these children, and anti-reflux surgery was carried out on one or both sides according to whether the abnormality of uretero-vesical implantation was uni or bilateral. In this small selected group, clinical and bacteriological results were similar to those obtained by anti-reflux surgery in children with radiologically detected vesico-renal reflux.

Child↗
PubMed1987

[Surgical complications of renal transplantation in children. Retrospective study of 372 cases].

On the basis of a personal series of 372 cases of renal transplantation performed in children, half of whom presented congenital urinary tract malformations, the authors report 110 complications (29.6%). The most frequent complications were urological (14.2%), consisting essentially of fistulae (8.9%) and stenoses (3%). These were followed by vascular complications (6.4%) generally in the form of stenoses (4.8%) and rarely thromboses (1.1%). The authors also report the various local complications which were infectious (wall abscess, suppuration of the renal compartment), haemorrhagic (haematomas) or stones (stones forming on non-resorbable sutures) as well as 5 cases of lymphocele. The prophylaxis of these complications depends on the care taken in collection of the graft (en bloc removal of both kidneys), the restoration of the continuity of the urinary tract (as much as possible Lich-Gregoire extravesical uretero-vesical reimplantation), the vascular anastomoses (vascular dissection limited to a strict minimum), the choice of suture material (resorbable synthetic suture material) and the prevention of infection by systematic pre-, intra- and post-operative antibiotic therapy.

Child↗
PubMed1987

[Urinary diversions and intestinal grafts in renal transplantation in children. Report of 8 cases].

In a series of 400 transplantations, 8 children presented a severe lesion of the lower urinary tract requiring an intestinal graft to divert the urine or to replace the useless bladder: 4 cases of posterior urethral valves and 4 cases of neurogenic bladder. Four permanent urinary diversions and 4 bladder enlargements, including 3 temporary diversions, were performed. The sigmoid colon was used in 5 cases and the ileum was used in 3 cases. The preparation of the intestinal graft was always performed prior to the transplantation. The uretero-intestinal anastomosis included an antireflux device in 3 of the 8 cases. There were no deaths in this series. Three occlusions and 2 lymphoceles occurred in the immediate post-transplantation period, but were corrected by re-operation. Two cases of calculi occurred in the long term, one of which required operation. Moderate stenosis of the renal artery in one case resulted in systemic hypertension which was well controlled by medical treatment. An episode of acute pyelonephritis resolved rapidly with antibiotic treatment. Two cases of acidosis were corrected by salt supplementation. There was one case of early graft rejection on the 15th day and a delayed rejection after 18 months, leading to removal of the transplant. At the present time, 6 renal grafts function normally (75%) with a follow-up of 1 to 8 years.

Adolescent↗