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J Crouzet

Publications and source records attributed to J Crouzet.

149 records · Page 9Linked to original sources
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Pyrithioxine and thiopronine: new penicillamine-like drugs in rheumatoid arthritis.

Two new SH-CH3-containing drugs have been studied as penicillamine-like agents. Pyrithioxine--retrospectively compared to a D-penicillamine series--was associated with fewer side effect-related withdrawals (14 vs 39) but with more non-responses and withdrawals for relapse. A review of the literature shows that thiopronine and D-penicillamine have a similar "score" of side effects and good responses. More extensively-controlled trials are needed for a better assessment of these new drugs.

Adult↗
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Autoantibody formation in D-penicillamine-treated rheumatoid arthritis.

One hundred and two rheumatoid arthritis patients were tested before treatment for the presence of 16 autoantibodies. Low titers of antinuclear factors appeared, but there were no antitissue antibodies. At different intervals during the treatment of a 2nd series of 176 patients, elevations of antinuclear factors were observed that correlated slightly with either autoimmune or toxic side effects. Antitissue antibodies were seen only in pemphigus and myasthenia after the onset of these complications. The practical value of systematic evaluation for autoantibodies in penicillamine-treated rheumatoid patients is questionable.

Adult↗
PubMedDate not supplied

[Study of 70 cases of rheumatoid polyarthritis treated by pyrithioxin with a 1-year follow-up].

The authors present their own series of 70 rheumatoidpolyarthritis cases treated with pyrithioxine during one year or more except in the case of failure or intolerance. The following results were observed after one year: 54 percent showed positive results, 34 percent showed no results or dubious ones, and there was 13 percent of discontinuance because of intolerance. Modifications of the posology and methods of administering are proposed, and the role of pyrithioxine, as a basic treatment for rheumatoid polyarthritis, is discussed.

Adult↗