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Biomedical subjects

J Cox

Publications and source records attributed to J Cox.

At least 217 records · Page 12Linked to original sources
PubMed1986

Surgery in primary leiomyosarcoma of the heart.

Primary leiomyosarcoma of the heart is uncommon and we were able to find only 15 cases reported in the literature. Few of these cases were discovered during life and, as a result, even fewer have been treated surgically. We report a case of a right atrial leiomyosarcoma which was proven pathologically (histologically, immunohistochemically and ultrastructurally) after surgical resection. The clinical presentation, morphological, appearances and outcome are compared with those reported in the literature.

Adolescent↗
PubMed1986

Atrial lead dislodgement with a DDD pacemaker.

A 48-year-old man with previous aortic valve surgery and aortic root repair had a DDD pacemaker inserted (using transvenous leads) for the treatment of complete heart block. An atrial J active fixation electrode was used. Four weeks following implantation the patient returned with an unusual electrocardiographic rhythm demonstrating two separate QRS morphologies. Both PA and lateral chest x-ray failed to demonstrate a change in lead position. The MARKER CHANNEL of the DDD pulse generator confirmed that the alternating QRS morphologies were due to atrial lead dislodgement. Although uncommon, displacement of atrial active fixation leads may occur and lead to unusual electrocardiographic rhythms. Use of a MARKER CHANNEL may aid in the diagnosis.

Electrocardiography↗
PubMed1986

Primary malignant lymphoma of the central nervous system. Results of treatment of 11 cases and review of the literature.

Eleven patients with primary malignant lymphoma of the central nervous system (CNS) were treated at the Medical College of Wisconsin Affiliated Hospitals between 1964 and 1984. Three patients had a prior history of immunosuppressive therapy following renal transplantation. All patients had biopsy-proven disease and 10 of the 11 were treated with external radiation therapy. The doses to the primary tumor ranged from 34 to 59.4 Gray (Gy). Actuarial (life-table) survival rate was 82% at 1 year and 43% at 3 years. No recurrence was seen after 13 months. Eighty-six reports totaling 693 cases of primary malignant lymphoma of the CNS were found in the literature. Of these, 308 cases were treated with a combination of surgery and irradiation. Overall survival at 5 years for those patients who received more than 50 Gy compared with less than 50 Gy to the primary tumor was 42.3% versus 12.8% (p less than 0.05). Twenty-one patients survived longer than 5 years. Late relapse was notable, with 10 (47.6%) of 21 tumors recurring between 5 and 12.5 years after diagnosis. Based on this review, a minimum of 50 Gy radiation to the primary tumor is recommended. While no statement regarding the efficacy of craniospinal irradiation or chemotherapy can be made in view of the small numbers, the use of craniospinal irradiation and/or systemic chemotherapy should be considered for future trials.

Adult↗
PubMed1985

Flow cytometric enumeration of absolute lymphocyte number in peripheral blood using two parameters of light scatter.

A method was developed to measure the absolute lymphocyte count (ALC) of whole blood using the Spectrum III automated flow cytometer. Ninety-nine samples of human peripheral blood were analysed on the Spectrum and the Coulter Counter S Plus II, to allow for comparison of the two machines. Regression analysis was used to test the extent of agreement between the sets of measurements on the two machines. The results demonstrated that the slope of the regression line was not significantly different from one, indicating a high level of correlation between Spectrum and Coulter ALC's. However, the mean difference between Coulter and Spectrum ALC's was not equal to zero, with the Spectrum giving counts approximately 10% lower than those of the Coulter machine. This is attributed to the different ways by which the two machines define a lymphocyte, the Spectrum III by two parameters of light scatter and the Coulter S Plus II by the single parameter of cell volume.

Flow Cytometry↗
PubMed1985

[Invasive pulmonary aspergillosis associated with an acute influenza virus infection].

We report a fatal case of invasive pulmonary aspergilloma (API) in association with an influenza A virus infection, occurring in a patient without any factor generally associated with a lowering of immunocompetence. There are five cases in the literature associating these two infections: the immunosuppressive effect of the influenza virus is possibly responsible for the mycotic invasive mass often encountered in the immunosuppressed.

Acute Disease↗
PubMed1984

Comparison of the analysis of delta 9-tetrahydrocannabinol capsules by high-performance liquid chromatography and capillary gas chromatography.

The modification of a high-performance liquid chromatography (HPLC) system and the development of a capillary gas-chromatographic (GC) system for the analysis of delta 9-tetrahydrocannabinol, encapsulated in soft gelatin capsules, are described. A photodiode array detector was used to evaluate peak homogeneity after each HPLC system modification. Sesame oil was separated from the extract by Sep-Pak filtration prior to GC analysis. Quantitation by both systems had r values greater than 0.999 and R.S.D. values less than 1.0%. Simultaneous capsule assays by both methods agreed within 1%.

Capsules↗
PubMed1984

General practitioner attendance at emergencies notified to ambulance control.

For two years doctors from a small village went to the scene of emergency calls received by ambulance control. On 80% of the occasions when the doctor was called at the same time as the ambulance was dispatched the doctor arrived before the ambulance. There were 24 incidents, 16 of which were road traffic accidents. In two cases the doctor established a clear airway in an unconscious patient before the ambulance arrived. Two patients were trapped in their vehicles and were given parenteral analgesics. Four patients required intravenous fluids. The call out system provided first aid for patients before the ambulance arrived and medical assistance to the emergency services at serious accidents. Patients who did not require hospital attention could be examined and treated at the scene, making the ambulance available for other duties and reducing the number of patients taken to the hospital accident and emergency department.

Accidents, Traffic↗
PubMed1984

Lymphocyte traffic in pregnant or oestrogen stimulated rats.

Lymphocyte migration was studied at three stages of rat pregnancy by the tracer sample principle of injecting syngeneic thoracic duct lymphocytes labelled with chromium-51 (for organ counting) or [3H]leucine (for autoradiography). Except for one abnormal embryo no entry of lymphocytes into the foetus was detected. There was a small localization of lymphocytes in the placenta which did not differ significantly between allogeneic or syngeneic mating. Pregnancy produced little or no alteration of lymphocyte traffic into the spleen or lymph nodes, including those draining the uterus. The administration of oestrogens to virgin rats increased the height of the specialized endothelium lining the post-capillary venules in the mesenteric lymph nodes but had no effect on lymphocyte traffic.

Animals↗