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Biomedical subjects

J Cote

Publications and source records attributed to J Cote.

45 records · Page 3Linked to original sources
PubMed1981

Renal clearance of digoxin in premature neonates.

The renal clearances of digoxin and creatinine were determined in seven premature neonates (mean gestational age = 29.9 wk, range = 26 to 36 wk) at a postnatal age of 1 to 9 days (mean = 4.1 days). The corrected renal digoxin clearance (mean, 10.4 ml/min/1.73 m2; range, 2.5 to 36.7) was highly dependent on gestational age and body weight, r being 0.95 and 0.96, respectively (exponential curve). The linear slope of corrected renal digoxin clearance vs. creatinine clearance plot approached unity (r = 0.99), indicating that digoxin and creatinine were handled similarly by the kidney in these premature neonates (i.e. glomerular filtration with some degree of tubular secretion). Our finding of slower renal digoxin clearance helps to explain the higher serum levels and longer half-life of this drug in premature neonates.

Creatinine↗
PubMed1977

Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland.

Identification of the beta-lipotropic hormone (beta-LPH)-producing cells in several species, including man, was performed with the technique involving use of the unlabeled antibody and peroxidase-antiperoxidase complex. Serial paraffin and ultrathin sections were treated for detection of both beta-LPH and ACTH at the light and electron microscopic levels. It was clearly shown that beta-LPH could be found only in the corticotropic cells located in the pars intermedia and pars distalis of all species studied. At the electron microscope level, it could be established that beta-LPH is contained in all the secretory granules of positive cells. These results suggest that beta-LPH is stored in the same secretory granules as ACTH and that both hormones are released together during granule extrusion.

Animals↗
PubMed1975

Noncirrhotic presinusoidal portal hypertension associated with chronic arsenical intoxication.

A 39-year-old male with bleeding esophageal varices due to portal hypertension was observed. The patient had taken an arsenical preparation during a period of 12 yr because of psoriasis and subsequently developed keratotic changes of the palms and soles of his feet and an epithelioma of the scrotum. Physical examination was unremarkable except for splenomegaly and skin lesions. Liver function tests were normal; a needle biopsy of the liver (right lobe) showed nonspecific changes. Combined hepatic and umbilicoportal catheterization revealed, on splenography and portography, huge esophageal varices and patent portal vein; dilation, distortion, and cut-off of many intrahepatic portal branches were found. A marked gradient existed between the free portal venous pressure (25 mm Hg) and the wedged hepatic venous pressure (9.5 mm Hg). Hepatic blood flow, portal PO2, cardiac output, cardiac index, and blOOD volume were within normal range. Arteriographies did not reveal arteriovenous shunts in the splanchnic or splenic vessels. A splenorenal shunt were performed and a wedged biopsy of the liver (left lobe) revealed nonspecific changes. Three years later the patient had not experienced any episode of hemorrhage or hepatic encephalopathy but developed an epithelioma of the tongue. No known cause could be incriminated in the pathogenesis of the portal hypertension. However, there was unequivocal chronic arsenic intoxication. Toxic hepatitis, cirrhosis, noncirrhotic portal hypertension, and hemangiosarcoma of the liver have been reported with the intake of arsenicals. Thus, it is suggested that in this patient, presinusoidal portal hypertension was secondary to chronic arsenical intake associated with marked intrahepatic vascular changes seen on portography.

Adult↗
PubMed1966

[Traumatic thrombosis of the internal carotid artery].

Two cases of post-traumatic thrombosis of the internal carotid artery are presented, which are of interest because of their relative rarity. A detailed understanding of the pathogenesis and variety of clinical presentations, an adequate appraisal of the diverse proposed treatments, and an improvement in the prognosis, which is poor even in young patients-these await further enquiry and research.

Adolescent↗
PubMed1965

[Bilateral thromboses of the internal carotid].

A recent case of bilateral internal carotid artery thrombosis encountered by the authors prompted a review of the literature on this subject. The lesion is compatible with, if not a normal life, at least prolonged survival, owing to the development of collateral circulation, which until the onset of thrombosis is of negligible proportions. The prognosis, although poor, may nonetheless be improved in future years if the practice is adopted of investigating the patient completely upon the appearance of the slightest symptoms. This may lead to early diagnosis and perhaps to better treatment results.

Angiography↗