[Effect of hypoglycemia on secretion of somatotropic hormone (STH) in myxedema].
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Biomedical subjects
Publications and source records attributed to J Corvilain.
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On the basis of 100 cases of hypercalcemia, the authors attempt to elucidate the criteria of the etiologic diagnosis. Kidney lithiasis or nephrocalcinosis suggested a primary hyperparathyroidism (HPT I) or an intoxication due to vitamin D. X rays of the skeleton and quantitative histological exams of the bone were not useful in the diagnosis of HPT I. The level of parathormone in the plasma is the best parameter to be used in distinguishing HPT I from other diseases. In the absence of renal insufficiency or severe intestinal disorders, a phospharemia below 2.6 mg/100 ml, a chloremia above 103 m EG/l and bicarbonates below 25 m Eg/l indicate an HPT I or a paraneoplasic. A phosphoremia above 3.2 mg/100 ml runs counter to this diagnosis. The chloremia/phosphoremia ratio is not more helpful than the phosphoremia alone.
Presentation of a case of cancer of the adrenal cortex with hypercorticism, treated by surgery and o,p'-DDD, with temporary clinical and biological remission. The indications and results of chemotherapy with o,p'-DDD are discussed.
Presentation of a case of Sipple's syndrome with bilateral malignant pheochromocytoma, bilateral thyroid medullary carcinoma and two parathyroid adenomas. The principal characters of the syndrome, the diagnostic tests, the necessity of a prospective survey of family relatives are discussed.
Up to 20% of isolated cold thyroid nodules are malignant neoplasms. However, in the case of 1-4 cm large nodules entirely cystic as demonstrated by echotomography, surgery is not necessary as the frequency of malignancy is only 1%. In cases of hot nodules the risk of cancer is regarded as almost nil, but such nodules can lead to thyrotoxicosis. Treatment by surgery or 131l will depend on the patient's age and condition; it must be performed for all hyperthyroid patients and, as a preventive measure, for all elderly or cardiac patients to prevent the consequences of even slight hyperthyroidism. The complete work up of a nodule requires not only scintigraphy and thyroid echotomography but also a careful clinical examination, tracheal X-ray, determination of serum antithyroid antibodies, assessment of thyroid function and, in some cases, trial therapy using thyroid hormones.
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