[Discussion on the surgical treatment of chronic obliterating atheroma of the arteries of the lower limbs. Therapeutic indications].
Explore the source record for details and available documents.
Aorta↗
Biomedical subjects
J Cormier
Publications and source records attributed to J Cormier.
[A case of arterial hypertension with renal artery lesions and other collateral lesions of the abdominal aorta (sub-tunica adventitia dissecting aneurysm)].
Explore the source record for details and available documents.
Accidents, Traffic↗
Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity.
BACKGROUND: Dendritic cells (DC) are potent professional antigen-presenting cells that can activate naive T lymphocytes and initiate cellular immune responses. As adjuvants, DC may be useful for enhancing immunogenicity and mediating tumor regression. Endogenous expression of antigen by DC could offer the potential advantage of allowing prolonged constitutive presentation of endogenously processed epitopes and exploitation of multiple restriction elements for the presentation of the same antigen. METHODS: DC were prepared from the peripheral blood of HLA A*0201 patients with metastatic melanoma in the presence of IL-4 (1000 IU/mL) and GMCSF (1000 IU/mL). Recombinant vaccinia and fowlpox viruses encoding the hMART-1 gene were constructed and used to infect DC. The efficiency of infection and expression of the MART-1 antigen were assessed by immunohistochemistry and intracellular FACS analyses. Cytotoxic lymphocytes (CTL) were generated by the stimulation of CD8+ T cells, with DC expressing the recombinant gene. Reactivity of the CTL was determined at weeks 1 and 2 by the amount of IFN-gamma released. RESULTS: DC were infected with recombinant poxviruses and demonstrated specific melanoma antigen expression by immunohistochemistry, immunofluorescence, and intracellular FACS analysis. The expression by DC of MART-1 MAA after viral infection was sufficient to generate CD8+ T lymphocytes that recognized naturally processed epitopes on tumor cells in 10 of 11 patients. CONCLUSIONS: Human DC are receptive to infection by recombinant poxviruses encoding MAA genes and are capable of efficiently processing and presenting these MAA to cytotoxic T cells. The potential advantage of this approach is the ability to present specific antigen independent of the identification of the epitope or the MHC restriction element. This strategy may be useful for the identification of relevant epitopes for a diverse number of HLA alleles and for active immunization in patients.
Antigens, Neoplasm↗
The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat.
Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations.
Adjuvants, Immunologic↗
A COMIT model utilization to improve first-case start time.
The purpose of this article is to review the problems and processes impacting the deviation in first-case actual start times when compared to first-case scheduled start times. This article will also discuss the Continuous Outcomes Measurement and Improvement Technique (COMIT) model for problem resolution and share the experiences encountered by a group of collaborative nurse manager leaders in their outcome improvement efforts. The overall process improvements are discussed using the eight-step COMIT model, which showed the overall success of the project.
Analysis of Variance↗