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Biomedical subjects

J Collignon-Brach

Publications and source records attributed to J Collignon-Brach.

At least 37 records · Page 2Linked to original sources
PubMed1982

Biometric study of the disc cup in open-angle glaucoma.

Stereoscopic and photogrammetric study of the disc cup in open-angle glaucoma reveals several morphological changes. The ovalisation of the cup, upwards, downwards or on the temporal side, appears early. It can be detected at the onset of the disease, even in the absence of visual field defects. It results in a localised thinning of the nervous rim, which is a characteristic sign of beginning glaucoma, but the depth of the cup is not increased even when perimetry already reveals important defects. The aim of this paper is to study, on the one hand, the morphological changes of the disc cup and on the other, the functional defects in open-angle glaucoma, and then to compare the results of the investigations.

Adult↗
PubMed1981

[Comparative clinical study of metoprolol and timolol (author's transl)].

Timolol is a non-specific beta-blocking agent acting on both beta 1 and beta 2 receptors while metoprolol is a specific beta 1 blocking agent. Both timolol and metoprolol decrease intraocular pressure by reducing aqueous humor secretion without increasing facility of outflow. They have both similar short and long term efficacy which does not diminish even after several months of use. Generally, there are adequate to treat glaucoma without perimetric changes, while treatment of glaucoma with functional defects requires their association with miotics. When blocking beta 1 receptors, timolol causes marked constriction of bronchi and peripheral vessels. Hence, it is contraindicated in bronchial asthma and ischemic optic neuropathy. This is not the case with metoprolol, which does not block beta 2 receptors.

Glaucoma↗
PubMed1980

[Treatment of primary closed angle glaucoma].

Surgery is the treatment of choice in angle closure glaucoma. Exceptions to this rule are rare. Peripheral iridectomy is the operation in reversible forms: asymptomatic forms, drug normalized attacks without anatomic alterations of the anterior segment, and when both eyes have the same biometry. Trabeculectomy is the treatment of all irreversible forms: attacks that are not controlled even with intensive medical management and subacute forms that progress to chronic angle closure glaucoma. Indication for combined cataract-trabeculectomy surgery are discussed in the text.

Acute Disease↗
PubMed1978

[Atenolol: its effects on pressure in open-angle glaucoma].

1. Instillation of 2 drops of 4% solution of atenolol decreases the ocular pressure in open angle glaucoma. 2. In 12 glaucomatous patients treated as in-patients, 4 daily instillations of 4% solution lower the average tension of the group below 20-22 mm Hg day and night. 3. The tensionnal effects of 4 or 6 daily instillations on out-patients seems to be less effective. 4. The hypotensive effects of atenolol, on some of the patients at least, decreases during the second month of uninterrupted treatment. However, the response to a single dose remains constant even after a long term treatment. 5. Treatment with atenolol is remarkably well tolerated. It does not provoke either local or general side effect. 6. Although the combination of atenolol and myotics or carbonic anhydrase inhibitors produces an additive pressure lowering effect this results in a loss of the advantages of atenolol with regard to absence of undesirable pharmacological effects.

Atenolol↗