Search PubMed⌕ Search

Biomedical subjects

J Coll

Publications and source records attributed to J Coll.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

[Results of psychomotor development in hypothyroidism detected at birth].

Thirty-five children in whom hypothyroidism was detected at birth were studied with respect to psychomotor development. A 5 year-follow-up was obtained in a few cases. The I.Q. was established using Brunet-Lezine's test or Griffith's test after age 30 months. Global quotients where normal: 98 + 10 at 6 months, 96 + 7 at 1 year, 99 + 7 at 3 years, 97 + 7 at 4 years and 97 + 4 at 5 years. Partial development quotients were normal concerning coordination and sociability. A transitory decrease was found at 1 year concerning posture and at 2 and 3 years concerning language, both returning to normal by age 4. These results were correlated with several factors: there was no significant difference between athyroidism and ectopia at the different ages but a difference appeared for partial development quotients at 2 and 3 years. There was no correlation between development quotients, clinical scores and dates of diagnosis. On the contrary, a significant correlation was found global development quotients at 6 months and the surfaces of epiphyses. Finally, a precise neurological evaluation showed an impairment of posture, coordination and fine movements of the extremities.

Congenital Hypothyroidism↗
PubMedDate not supplied

Tuberous sclerosis: a Golgi study of cortical tuber.

The cytoarchitecture and fine structure of seven cortical tubera were studied by means of camera lucida drawings and Golgi sections in the coronal, sagittal, and tangential planes. Varied structural disorganization was observed in different tubera. Cytoarchitectural study revealed the absence of laminar and columnar cortical organization, whereas Golgi's method showed abnormal neuronal orientation and distribution. Pyramidal neurons manifested malrotation and orientation of the apical dendrites in aberrant directions. Large numbers of stellate cells in addition to medium-sized and small pyramids predominated in the intermediate and deep regions of the tubera. A generalized but focally accentuated disorder of cell migration and neuronal organization is postulated.

Adult↗