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Biomedical subjects

J Colin

Publications and source records attributed to J Colin.

At least 73 records · Page 4Linked to original sources
PubMed1995

[Comparative prospective study of effects of Biovisc and Healonid on endothelial cell loss and intraocular pressure in cataract surgery].

PURPOSE: The goal of this trial was to evaluate the efficacy (protective action on corneal endothelium and ability to facilitate the procedure) as well as safety (effect on intraocular pressure and inflammation) of Biovisc (new viscoelastic agent made of 1% sodium hyaluronate produced by bacterial fermentation) versus Healonid) postcataract surgery (manual or phacoemulsification). METHODS: 106 patients, 45 males and 61 females (31-94 years) were included in this prospective randomized multicentre trial and followed up for three months. Specular microscopy and intraocular pressure (IOP) measurement were the main evaluation criteria. RESULTS: At D 90, no significant difference was observed between the two viscoelastic agents on the mean endothelial cell loss (group Viovis: -8.6%; group Healonid: -6%) as well as on IOP (early peaks were transitory and resolutive). CONCLUSION: Biovisc and Healonid were similar in terms of efficacy and tolerance.

Adult↗
PubMed1995

[Value of serodiagnosis of Lyme disease in the evaluation of uveitis].

PURPOSE: This study was designed to assess results of Lyme serology among all the specific tests routinely performed for exploring uveitis. METHODS: Sixty-seven patients examined for uveitis had a serological diagnosis of Lyme's disease with haemagglutination test and ELISA IgG test. This group included 34 patients with unclassified uveitis. Thirty-seven healty individuals served as control subjects. RESULTS: There was no statistical difference between the three groups in terms of positive serological diagnosis occurrence: control subjects (13.5%), patients with classified uveitis (12.1%) and patients with unclassified uveitis (11.8%). CONCLUSION: It appears to be more adequate to reserve this serological test for Lyme's disease for patients who have a suggestive history or additional symptoms.

Adult↗
PubMed1995

Identification of the T cell antigen receptor V beta gene products in labial salivary glands from patients with primary Sjögren's syndrome.

T lymphocytes are predominantly involved in the development of Sjögren's syndrome. Their repertoire has recently been claimed to be restricted. Analysis of T cell receptor V beta gene products within the labial salivary glands led us to identify V beta 2 and V beta 8. This study, using a new panel of anti-V beta product monoclonal antibodies and a tissue triple-staining technique, examined the distribution of V beta gene family products in activated as well as non-activated CD4+ or CD8+ T cells subsets in the salivary gland tissue of SS patients. Our results suggest that the V beta genes used by the T CD4+ or T CD8+ cells in situ are similar, irrespective of the activation status of these cells. T lymphocytes homing into exocrine tissues might thus be selected on the basis of their V beta repertoire rather than their activation state.

Adult↗
PubMed1995

[Neuropapillitis in Behçet disease. A case].

The authors report the case of a 34 year old woman, who developed acute neuropapillitis, which appeared to be the first ophthalmologic manifestation of Behçet's disease. One year later, this patient recurred with another neuro-ophthalmologic sign: a sixth nerve palsy.

Abducens Nerve↗
PubMed1995

[Intrastromal thermokeratoplasty for correction of spherical hyperopia: a 1-year prospective study].

Thermokeratoplasty (TKP) is a new procedure for surgical correction of hyperopia. It uses controlled thermal burns of the peripheral cornea with a retractable cautery probe tip in a radial pattern up to a premarked optical central zone. The thermal effect shrinks the peripheral cornea and steepens the central cornea. In this report, we prospectively evaluated for one year, anatomical, functional and refractive results of a group of 18 eyes treated with TKP (14 patients). Mean preoperative spherical equivalent of +3.62 diopters (D) was +1.85 D at 12 months resulting in a mean refractive variation of -1.76 D. The refractive effect was significant at the first postoperative month, and subsequently regressed so that the average refractive correction was 55% at one year. We did not observe any severe anatomical or functional complications during the follow up period. Regression of the refractive effect after TKP seems to be related to the remodeling response of corneal stroma surrounding points of coagulation. Like other current techniques of surgical correction of hyperopia (hexagonal keratotomy, TKP using Holmium-YAG laser, Excimer laser), TKP is a procedure for which optical results at one year show poor predictability and stability. We suggest that adjustments to the surgical prediction software and long term studies would allow to improve our results.

Adult↗
PubMed1994

Clear lensectomy and implantation of low-power posterior chamber intraocular lens for the correction of high myopia.

BACKGROUND: Although a variety of surgical procedures to treat high myopia have been studied, no consensus exists on the optimum procedure. Clear lensectomy with implantation of a posterior chamber intraocular lens has been regarded as risky, due to the higher incidence of retinal detachment in highly myopic eyes. METHODS: The authors performed surgery and evaluation over 1 year in 52 eyes in which prophylactic retinal treatment, clear lensectomy, and posterior chamber intraocular lens implantation were used to treat high myopia of 12 diopters (D) or greater. RESULTS: Before lens extraction, 31 eyes underwent argon laser photocoagulation. Over the 1-year period, three additional eyes were treated, and six eyes that had been treated preoperatively received additional treatment. No cystoid macular edema, retinal detachment, or persistent corneal edema was observed in this series. At 1 year, 88.5% of the group achieved corrected visual acuity of 20/40 or better, compared with 75% preoperatively. Uncorrected visual acuity of 20/100 or better was achieved by 84.6% of the group. The mean postoperative spherical equivalent was -0.86 +/- 0.84 D. CONCLUSION: The refractive objectives were achieved. Complications reported previously with clear lensectomy were not experienced in this group. The low incidence of complications can be attributed to the short follow-up and probably in part to the prophylactic retinal treatment, combined with the phacoemulsification procedure for lens extraction. Longer follow-up is needed to fully assess the complications. Properly randomized prospective clinical trials will be able to fully assess the benefits and risks of prophylactic retinal treatment and clear lens extraction with posterior intraocular lens implantation. This series can help in evaluating this surgical procedure.

Adult↗
PubMed1994

[Keratoconus and familial topographic corneal anomalies].

PURPOSE: Computer-assisted corneal topography, allows the detection of early abnormalities, including abortive or subclinical forms of keratoconus. So, it is possible to identify affected individuals with variable degrees, in family members of patients with keratoconus, to draw pedigrees, and to specify the mode of inheritance. METHODS: Computer-assisted digital videophotokeratoscope was used to map the corneas of 106 family members of 30 patients with keratoconus. RESULTS: Abnormalities observed included the inferior cornea markedly steeper than the superior cornea (I-S - 0.86 +/- 0.44 D) and a marked difference between the central corneal powers of the two eyes (delta PC = 0.72 +/- 0.22 D). However, there was no statistical difference with normal individuals for central corneal power. CONCLUSION: Pedigree analysis in these families suggests, in 50% of them, an autosomal dominant mode of inheritance. However, it is impossible to conclude for the other families, because of an insufficient number of cases.

Adult↗
PubMed1994

[Treatment by refractive photokeratectomy of undercorrections after radial keratotomy].

UNLABELLED: Residual myopia after radial keratotomy is one of the major problems of this technique, it may be corrected with laser keratectomy. MATERIALS AND METHODS: We present the results of nine eyes treated with photorefractive keratectomy, due to undercorrection after radial keratotomy. The photoablation was performed with the laser VISX 20/20, wavelength 193 mm, and concerned a residual spherical equivalent myopia (after RK) with an average of -2.00 diopters and a range of 0.87 to -3.75 D. RESULTS: Six months postoperatively, the average spherical equivalent refraction was no greater than -0.75 D and a range of -0.25 D to -2.12 D; 66.7% were within +/- 0.5 D of emmetropia, with a uncorrected visual acuity > 10/20. The best corrected visual acuity remained nearly the same. Postoperatively functional symptomatology and healing processus are comparable to the first intention of photoablation. CONCLUSION: The safety and effectiveness of laser Excimer photoablation seem to be demonstrated and this procedure could be used to complement RK.

Adult↗
PubMed1994

[Exfoliative syndrome and phacoemulsification].

PURPOSE: Exfoliation syndrome (ES) is often considered as a poor indication for phacoemulsification because of zonular weakness, capsular weakness and poor pupil dilatation. METHODS: We evaluated from January 1992 to December 1992 a series of 107 consecutive eyes with ES and undergoing cataract surgery or combined cataract-glaucoma surgery. The pupil was surgically enlarged if the diameter was < or = 5 mm. RESULTS: During surgery, only one case of zonular dialysis without vitreous loss was observed. The incidence of postoperative complications was low (6 hyphemas and 8 inflammatory reactions) and visual results were satisfactory. CONCLUSION: Phacoemulsification can be used routinely in eyes with ES if a careful peroperative protocol is followed: pupillary dilatation, wide capsulorhexis, total nucleus hydrodisection.

Aged↗
PubMed1994

[Corneal endothelium in uveitis].

The authors report the results of a prospective study concerning corneal endothelium during uveitis. They compared 65 patients (87 eyes) suffering from uveitis (divided into four groups: anterior uveitis, pars planitis, posterior uveitis, total uveitis) with a control group (36 eyes, same age). The results showed a decrease of the endothelial cell counts in the uveitis group. However this difference was not significative (Student test t). There is no difference in the endothelial cell count between each group of uveitis.

Adult↗
PubMed1994

[Infectious crystalline keratopathy occurring after penetrating keratoplasty].

Infectious crystalline keratopathy is a chronic corneal infection, characterized by interlamellar opacities that are shaped like crystal formations. In the majority of cases, Streptococcus viridans is cultured. We report the case of a 74 year old man, presenting with corneal infection in a donor graft after penetrating keratoplasty. A Streptococcus sanguis was isolated. The clinical response to antibiotics was poor, with a slow and inexerable progression, leading to possible corneal regrafting.

Aged↗
PubMed1993

Contact with AIDS patients as a source of work-related distress: effects of organizational and social support.

In this study, we hypothesized that a nurse's exposure to acquired immunodeficiency syndrome (AIDS) patients as part of the work role is positively associated with distress as indexed by negative mood at work. Given this expected relation, we sought to identify factors that might reduce the negative effects of caring for AIDS patients on nurses. We predicted that both organizational and social support would moderate the relationship between extent of exposure and negative mood, with the relationship being strongest when support is low and weakest when support is high. The results of tests among a sample of 256 nurses supported all the hypotheses. We discuss implications of this study and directions for future research.

Acquired Immunodeficiency Syndrome↗