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Biomedical subjects

J Coleman

Publications and source records attributed to J Coleman.

177 records · Page 10Linked to original sources
PubMedDate not supplied

TGF-beta3 in the treatment of pressure ulcers: a preliminary report.

OBJECTIVE: To determine the safety, tolerability, and efficacy of TGF-beta3 in the treatment of chronic, nonhealing pressure ulcers. DESIGN: A subset analysis of data from a randomized, blind, parallel, placebo-controlled trial involving 270 patients. SETTING: University of Michigan Wound Care Center. PATIENTS: A total of 14 patients (6 women and 8 men aged > or = 18 years) with pressure ulcers were randomly assigned to 1 of 3 groups to receive once daily topical application of recombinant TGF-beta3 or placebo gel for a period of no more than 16 weeks. Group 1 (n=4) received 1.0 microg/cm2 of TGF-beta3, Group 2 (n=5) received 2.5 microg/cm2 of TGF-beta3, and Group 3 (n=5) received placebo gel. All subjects received standardized wound care as well. Weekly evaluations were performed for efficacy, determined by relative wound surface areas and volumes, and were compared with initial baseline values and safety parameters. MAIN OUTCOME MEASURE: Reduction in pressure ulcer area and volume. MAIN RESULTS: Group 2 had a significantly increased rate of wound healing at the fourth visit (P<.05). No significant difference was observed in the healing rate among the groups at the termination of the study. Treatment with TGF-beta3 was well tolerated and there were no significant adverse reactions. CONCLUSION: The findings of this study indicate that the topical application of TGF-beta3 is safe and useful in the treatment of pressure ulcers and is most effective at the earliest stages of therapy.

Administration, Topical↗
PubMedDate not supplied

Expanding the scope of educational psychology.

This paper describes the way in which a psychologist has workded in day nurseries in an Inner London Borough. The work has involved the development of an assessment form to be used with the children, and the planning of support groups for the day nursery staff. A brief outline is given of the research design necessary to evaluate the effectiveness of this intervention. It is to be hoped that the study indicates one way in which educational psychologists may extend their range of activities into the preschool area, and maximize the use of their skills in the field of childhood disadvantage.

Child Behavior Disorders↗
PubMedDate not supplied

Action research in day nurseries: evaluating programmes through staff perceptions and attitudes.

Day nurseries in deprived inner-city areas have to cope with a wide range of problems which are presented by the young children and their families. Many of the children can be delayed in some area of their development or have emotional problems which require sensitive handling. These challenges are in addition to the expected difficulties of helping young children to adjust to a new situation and the presence of unfamiliar adults and children. The staff of day nurseries tend to be young and the 2-year training has a great deal to cover on normal development. The consequence is that staff in their late teens and early twenties have to face the demands of children whose development is often far from 'normal' in terms of the average range. It was a concern about this situation in a very disadvantaged area of London and the fact that nurseries have traditionally been fairly isolated institutions that led to the planning of a 2-year exploratory project with the objective of introducing new ideas and approaches to nursery staff which would help them provide a better quality of care to socially disadvantaged under-5s.

Attitude↗
PubMedDate not supplied

Every man for himself.

Explore the source record for details and available documents.

Health Education↗
PubMedDate not supplied

The effect of suture material on platelet deposition onto prosthetic material.

Previous studies have demonstrated the importance of employing prosthetic material with minimal thrombogenicity. However, the role of different suture materials in early thrombotic events on prosthetic materials has not been examined. Experiments were designed to analyze the effects of suture on platelet graft interaction using an in vivo baboon hemocompatability screen. 111Indium labeled, autologous platelet deposition was determined on expanded polytetrafluoroethylene (ePTFE) containing suture lines of polypropylene (Prolene), polybutester (Novafil), and ePTFE (Gore-Tex). A significant increase in platelet deposition was noted not only at the suture line, but proximal and distal to it as well. The results were different for each of the sutures employed and suggest that the suture line may influence early platelet deposition in the perianastomotic region, not only at the suture line, but proximally and distally as well.

Animals↗
PubMedDate not supplied

A multicenter study of costs and nursing impact of cartridge-needle units.

A multicenter study of the overall costs and impact on medication administration of sterile cartridge-needle units (Carpuject) and conventional disposable syringes with multiple- and single-dose vials was conducted in six hospitals in the Voluntary Hospitals of America (VHA) system. Data collection involved a time and motion phase measuring procurement, preparation, and disposal of both systems and a 6-month prospective global cost analysis of component costs, waste disposal, nursing time, needlestick injuries, and subsequent treatment. Nonacquisition costs were substantially lower with the use of the cartridge-needle units. When all costs are considered, sterile cartridge-needle units are a cost-effective alternative to conventional disposable syringes and multidose vials.

Cost-Benefit Analysis↗