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Biomedical subjects

J Cobb

Publications and source records attributed to J Cobb.

66 records · Page 4Linked to original sources
PubMed1979

Morbid jealousy.

Explore the source record for details and available documents.

Adult↗
PubMed1978

Effects of signal rise time and frequency on the brainstem auditory evoked response.

Two experiments studied the effects of signal rise time and frequency on the brainstem auditory evoked response. In Experiment 1, five different rise times were presented, fast (10 microseconds), 0.5, 1, 2.5, and 5 msec at a center frequency of 1000 Hz at three sensation levels, 20, 40, and 60 dB. As rise time was increased, response amplitude and detectability decreased and response latency increased. In Experiment 2, tonal pips were presented at 250, 500, 1000, 2000, 4000, and 8000 Hz at 40-dB sensation level. Although the effects of frequency and signal rise time were confounded, no frequency effect was apparent.

Acoustic Stimulation↗
PubMed1972

Congenital dyserythropoietic anaemia with erythroblastic multinuclearity.

A case of congenital dyserythropoietic anaemia with erythroblastic multinuclearity in a 36-year-old woman is described and the literature reviewed. The syndrome is characterized by a protracted clinical course, a relatively mild anaemia, a low reticulocyte count, slight hyperbilirubinaemia, splenomegaly, pronounced erythroid hyperplasia with reversal of the myeloid erythroid ratio, and in particular by the presence of multinucleated erythroblasts in the marrow. The picture of ineffective erythropoiesis is confirmed by erythrokinetic studies. The present case is the forty-first to be described in the literature and is the third from Britain. Thirty-one of these have occurred in seven families but a family history has been lacking in the remaining ten. The onset of anaemia occurred in childhood in 21 of the 41 cases.

Adult↗
PubMedDate not supplied

Discussions regarding aggressive care with critically ill patients.

Protocols concerning orders not to resuscitate have come into existence recently in order to facilitate decisions regarding resuscitation and to ensure that patient's rights to participate in such decisions are preserved. Prior to the do-not-resuscitate (DNR) decision is the decision whether to discuss the issue of resuscitation with the patient at all. To determine how frequently physicians discuss this issue with their patients, the authors gathered information on all 611 patients admitted to the medical intensive care unit (MICU) or the cardiac care unit (CCU) at a tertiary care teaching hospital over a nine-month period. They found that the issue was discussed with only 10.8% of patients or their families on admission of the patients to these units. Such discussions occurred more frequently with older patients, those who were more severely ill or were estimated to have worse prognoses, those with poor intellectual function, and those admitted to the MICU rather than the CCU.

Aged↗
PubMedDate not supplied

Gadolinium cryptelates as MR contrast agents.

Gadolinium cryptelates are complexes of a lanthanide metal ion with amino acids of macrocyclic polyamines. These compounds are water soluble and possess reduced relaxation properties similar to Gd diethylene triamine pentaacetic acid (DTPA). Three Gd cryptelates (Gd NOTA, DOTA, TETA) were evaluated. Gadolinium DOTA is the most stable Gd complex with a dissociation constant of 10(-28) and appears to have a greater serum stability than Gd DTPA. Gadolinium NOTA and Gd TETA have lower dissociation constants than Gd DTPA at 10(-17) and 10(-19). Gadolinium DOTA has tissue distribution properties similar to Gd DTPA, is rapidly excreted by the kidneys, and provides a high degree of contrast enhancement on magnetic resonance (MR) images, both systemically and within the CNS. Hence, Gd DOTA is an alternative water-soluble MR contrast agent to Gd DTPA.

Animals↗
PubMedDate not supplied

Creutzfeldt-Jakob disease in a recipient of a dura mater graft processed in the US: cause or coincidence?

Iatrogenic Creutzfeldt-Jakob disease (CJD) has never been reported among recipients of dura mater grafts processed in the US. We recently investigated a report of such a case in a 72-year-old man with a typical clinical presentation of CJD. We found no evidence of CJD in either the 34-year-old donor or in other, proximal patients undergoing craniotomies. Although the graft may have caused the illness, sporadic CJD is a more likely explanation, with the graft being coincidental.

Adult↗