Search PubMed⌕ Search

Biomedical subjects

J Clough

Publications and source records attributed to J Clough.

27 records · Page 2Linked to original sources
PubMed1988

Uncontrolled trial of cryofiltration in rheumatoid arthritis.

In an open trial of cryofiltration in rheumatoid arthritis at our institution, 19 patients received 464 treatments; the intensive schedule of ten treatments in 5 weeks was completed in 14 of the 19, and excellent to good clinical response was achieved in ten of these. The combined results demonstrated significant reductions in Ritchie index, morning stiffness, and 50-foot-walk time in the intensive treatment period, as well as significant increases in hand grip strengths. In the maintenance treatment period treatment frequency was individually selected and at less frequent intervals. Changes in clinical parameters were notably less. Although significant correlations were observed between the percent change in clinical parameters and the percent change in biochemical and hematological parameters, no consistent pattern was found. The favorable results of this trial and other uncontrolled trials has led to a two-center double-blind controlled trial of cryofiltration in rheumatoid arthritis that is now in progress.

Adult↗
PubMed1982

A bioequivalence study of three preparations of propranolol.

The bioequivalence of two different tablets and a solution, each containing 10 mg propranolol hydrochloride was studied in twelve healthy volunteers. Single oral doses of each preparation were administered at intervals of one week. Samples of blood for propranolol radioimmunoassay were taken up to 8 h after dosing. The plasma propranolol concentration at 0.5 h was significantly higher for the solution than for the two tablet formulations which did not differ significantly from each other at any sampling point. The area under the curve was similar for all three preparations. The study demonstrated that the three different preparations of propranolol were bioequivalent.

Adult↗
PubMedDate not supplied

A propranolol radioimmunoassay and its use in the study of its pharmacokinetics following low doses.

A radioimmunoassay has been developed for propranolol with a sensitivity of 2.37 nmol l-1 in unextracted plasma using a 50 microliter sample. Plasma concentration measurements were made on samples from volunteers for up to 8 h after they had been given 5, 10, or 40 mg of propranolol by mouth. Analysis of the results showed that mean elimination half-lives and total body clearances were similar following each of the doses and that the area under the curve was proportional to the dose. Steady-state propranolol concentrations in 17 patients on regular propranolol treatment were linearly related to the dose ver the range 20-640 mg d-1; the regression line extrapolated to the origin. These data indicate non-saturable kinetics for the hepatic metabolism of propranolol within the dose ranges investigated and lead us to believe that there is no 'oral-threshold' dose for propranolol. The radioimmunoassay may be useful in clinical practice for monitoring plasma propranolol concentrations and for detecting patient compliance.

Adult↗
PubMedDate not supplied

Assessing and controlling risk.

This article describes the principles of risk assessment in the workplace. It outlines regulations relating to health and safety at work as they affect nursing, and goes on to discuss both qualitative and quantitative risk assessment.

Education, Nursing, Continuing↗
PubMedDate not supplied

Act on equality.

Explore the source record for details and available documents.

Persons with Disabilities↗
PubMedDate not supplied

Antibodies to the human T lymphocytotropic type I in systemic lupus erythematosus.

We tested sera from 94 patients with systemic lupus erythematosus (SLE) by Western immunoblot. Using the criteria established by the Public Health Service Working Group, 11 (12%) sera were reactive, 29 (31%) indeterminate and 54 (57%) unreactive. When the reactive sera were immunoblotted against an extract from an uninfected control lymphoblastoid cell line, identical bands were obtained. HTLVI antigenemia could not be detected in any of the reactive sera. This suggests that previously described "antibodies to HTLVI" in SLE represent artifactual reaction with cellular components in the antigenic extract.

Blotting, Western↗