Search PubMed⌕ Search

Biomedical subjects

J Clemmesen

Publications and source records attributed to J Clemmesen.

At least 19 recordsLinked to original sources
PubMed1997

[Is smoking during pregnancy a cause of testicular cancer?].

Smoking during pregnancy is suggested as a cause of the increasing incidence rates of testis cancer in Denmark, particularly for the age group between 25 and 50. Testis cancer is associated with lower birthweights, as is smoking during pregnancy. Danish women have rates of everyday smoking amongst the highest in Europe, and the highest rate of smoking during pregnancy in Scandinavia, followed by Norway, Sweden and Finland. Incidence rates for testis cancer show the same sequence. The increasing incidence of testis cancer in Copenhagen was temporarily halted among men bom between 1939-1945 during the wartime tobacco shortage. The maternal generation aged about 25 years during the war years shows a corresponding delay in the increasing incidence of lung and bladder cancer, with a lag-time of respectively 20 and 30 years. The author recommends long-term followup of newborn boys prenatally exposed to tobacco.

Adult↗
PubMed1997

Is pregnancy smoking causal to testis cancer in sons? A hypothesis.

Inquiry studies into smoking during pregnancy as a possible cause of testis cancer in sons are found misinterpreted as purely negative. Danish quinquennial incidence rates for patients aged 25-39 years are compared with rates for tobacco-induced neoplasms among the corresponding maternal generation, primarily of bladder tumours including papillomas, and of lung both for ages 50-64 years, allowing for period of latency. Corresponding to a delay of increase, earlier demonstrated for incidence rates of testis cancer among men born 1939-1945, delays of increase are found for female bladder and lung with allowance for lag-times of 30 and 20 years respectively. Comparison of data from Scandinavian nationwide cancer registries show a noteworthy parallelism of trends from first to last plotting of testis/female bladder ratios. The rise for lung is found steeper in consequence of age distribution.

Adult↗
PubMed1989

Antitumor effect of lactobacilli substances: "L. bulgaricus effect".

Scattered reports suggest a moderate effect, difficult to reproduce, of products from strains of specific lactobacilli (L. bulgaricus) used for yogurt on cancer and leukemia in mice. Skeptics have disregarded that even lyophilized preparations of demonstrated activity will lose effect when stored above -80 degrees C. This explains some inconsistencies of results and difficulties in repetition. Flow DNA fluorometry of ascitic fluid from leukemic mice has shown some accumulation of cells in the G2 + N phase after 8 hours, clearly different from the effect of 5-fluorouracil, although occasionally similar in strength. The effect depends on the strain of lactobacilli, and seems to deserve rational analysis by modern methods.

Animals↗