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Biomedical subjects

J Claustre

Publications and source records attributed to J Claustre.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Changes in blood levels of noradrenaline in man following short and long term exogenous infusion].

Norepinephrine (NE) was infused in four normal men in doses of 1.5, 6.0 and 9.0 microgram/min for 60 min. The rise in plasma NE was observed only after 5 min and steady state plasma NE and infusion rates. The calculated turnover time averaged 35 sec for 1.5 microgram/min infusion and 20 sec for both 6.0 and 9.0 microgram/min infusion experiments. These differences may be explained by adjustments occurring in inactivation processes in relation to infused doses. A basal endogenous overflow rate of 15 ng kg-1 min-1 was calculated for NE. In the month following NE infusion plasma concentrations decreased exponentially but remained above preinfusion values during about 10 days. The above results confirm the important role of inactivation mechanisms to remove NE from plasma and show that the amine taken up by sympathetic neurons may be released over a long period following the end of infusion.

Adult↗
PubMed1979

[Rheumatoid foot. Practical podiatric problems].

The rheumatoid foot may obtain relief from practical local measures that prevent the excessive use of drug therapy. These include the decrease in inflammatory phenomena thanks to local injections of corticoids (eventually synoviorthesis), the prevention of deformations through the use of various apparatuses, the protection of the skin of the palms and the nails that are fragile and rapidly altered by local hygiene care. The maintaining of sufficient support and normal walking through the use of plantar prostheses or custommade toe prostheses and by wearing shoes of excellent quality, the maintainance and preservation of articular flexibility and muscular trophicity by adapted kinestherapy and ergo therapy. Major deformations that, while they cannot be modified do not require surgery, can be alleviated with "custom-made shoes" which are at the same time light, adapted and good looking. Whatever the treatment used, local measures are the most effective at any given time.

Adrenal Cortex Hormones↗
PubMed1976

[Xeroradiography in rheumatology].

Xeroradiography is a new and simple radiodiagnostic technique that makes it possible to analyse on one positive film not only the bone tissue but also the neighbouring structures (ligaments, muscles, fatty tissue, the vessels, and the skin). On the basis of about 100 examinations, the authors indicate the value and the limitations of the technique in rheumatological practice. Because of the technical aspects of the technique, the dorsolumbar spine and the facial massif are poorly visualized. The swamping of the contrast also limits its use for cases of demineralization (osteoporosis). On the other hand, the information provided by the technique in cases of Paget's disease, articular or para-articular calcification, pathological conditions of the tendons (rupture, calcification), and bone tumours appears to be of great value. The early diagnosis of cases of inflammatory rheumatism and the surveillance of Silastic prostheses used in surgery on rheumatic hands are also facilitated.

Arthritis, Rheumatoid↗
PubMed1976

[Foot involvement in Paget's disease of bone].

Paget's disease of the bones of the feet is not unusual. Twenty patients out of every hundred present the signs of Paget's disease in the foot bones. The calcaneus is the bone most often affected (18 cases) but the cuboid, the metatarsals, and the astragalus (often as well as the calcaneus) may also be affected. Paget's disease of the foot remains latent clinically: 2 patients complained of talalgia; a third had a deformation of the rear part of the foot which made it difficult to wear a shoe. Pagetic deformations of the lower limb affect the foot but without pain. They are often compensated for by putting more weight on the fore-foot in cases of shortening of the lower limb or on the external arch in cases of bowed deformation of the lower limb.

Adult↗
PubMed1975

[Etiology of Paget's disease of bone].

The etiology of Paget's disease is just as doubtful in 1975 as it was in 1876 when Sir James Paget described the disease. The authors analyse the etiology on the basis of 100 personal cases and the literature. Although there are undoubtedly familial cases of the disease, investigation of the leucocyte grouping of 46 patients with Paget's disease did not reveal any correlation between occurrence of the disease and the HL-A antigens. Various pathological associations have been reported in the literature and were also found in this series. These associations were at the limits of coincidence (inflammatory rheumatism, diffuse chondrocalcinosis, multiple myeloma...). Metabolic changes (hyperuricaemia, hyperglycaemia, dyslipidaemia) did not appear to be more frequent than in control patients. Involvement of elastic tissue and the presence of pseudocrystalline inclusions in the osteoclasts constitute interesting points for discussion.

Adult↗