Search PubMed⌕ Search

Biomedical subjects

J Clausen

Publications and source records attributed to J Clausen.

At least 199 records · Page 11Linked to original sources
PubMed1975

Correlation between incorporation of myo-(2-3H)inositol into the phosphatidylinositol of lymphocytes and disability degree, stage and duration of multiple sclerosis.

The present study revealed a positive correlation between the degree of disability of MS patients and the rate of incorporation of myo-(2-3-H)inositol into phosphatidylinositol of lymphocytes stimulated with basic protein (BP) and phytohemagglutinin (PHA). No correlation could be found between the response of lymphocytes to measles antigen (MA) and the degree of disability, stage and duration of multiple sclerosis. No correlation could be observed between the response of lymphocytes to the stimulants studied and the duration of the disease.

Adult↗
PubMed1975

Morphological changes of astrocyte-like cells induced by serum beta-lipoprotein in brain cell culture.

When added to brain cell cultures of newborn rats, serum and, in particular, its beta-lipoprotein fraction caused significant morphological transformations of astrocyte-like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of beta-lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte-like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood-brain and blood-spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum beta-lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.

Animals↗