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Biomedical subjects

J Civatte

Publications and source records attributed to J Civatte.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Smooth muscle hamartoma or nevus of Becker? Apropos of 4 cases].

Theoretically, Becker's melanosis or hairy epidermal nevus and smooth muscle hamartoma are two quite separate entities. In fact, there are cases which could be considered as intermediate. As a matter of fact, a slight underlying smooth muscle hyperplasia can be seen in Becker's nevus; on the other hand, hypermelanosis of the basal layer and hypertrichosis may be encountered in smooth muscle hamartoma. The 4 here reported cases are examples of diagnostic difficulties for which the sometimes not clear-cut limits of these 2 types of lesion can be responsible.

Adult↗
PubMed1988

Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma. Report of 2 cases.

Two cases of malignant acanthosis nigricans associated with non-Hodgkin's lymphoma are presented. A 61-year-old negro male with a diffuse large cell non-Hodgkin's lymphoma presented extensive acanthosis nigricans, pachydermatoglyphy and florid cutaneous papillomatosis. No viral particles were observed by electron microscopic studies of the wart-like lesions. Acanthosis nigricans disappeared under chemotherapy. The second case was a 21-year-old caucasian male with non T non B diffuse large cell non-Hodgkin's lymphoma. Very few cases of acanthosis nigricans associated with non-Hodgkin's lymphoma have been reported in the literature, since to our knowledge these two are only the fourth and fifth. Pachydermatoglyphy and florid cutaneous papillomatosis are markers of malignant acanthosis nigricans.

Acanthosis Nigricans↗
PubMed1988

Prediction of benzoyl peroxide phototoxicity by photoepidermotests after repeated applications. Preventive value of a UVB filter.

The predictive phototoxicity test known as photoepidermotest consists of twice daily applications of the product tested for 16 days, followed by total spectrum irradiation with a 2,500-W Xenon lamp in infraerythema and supraerythema doses. Phototoxicity is revealed by an erythema with the infraerythema dose and/or by accentuation of the erythema provoked by the supraerythema dose when compared with the "irradiation only" (i.e., no product) control skin area. This technique, used in a controlled, double-blind trial, showed that a 10% benzoyl peroxide (BPO) gel was phototoxic in eight out of 18 subjects tested (44%). It also showed that adding a UVB filter (phenylbenzimidazole sulfonic acid 1%) to the BPO preparation was effective in preventing phototoxic reactions in seven of these eight subjects.

Adult↗
PubMed1987

2% topical minoxidil solution in male-pattern baldness: preliminary European results.

A 48-week, double-blind, randomized study was conducted in France, West Germany and the UK to compare the safety and efficacy of topical minoxidil 2% (Regaine; registered trade mark of the Upjohn Company) solution with placebo in the treatment of early male-pattern baldness. At week 24, the end of the placebo period, there were 225 evaluable patients, 116 in the treatment group and 109 in the placebo group. The 2% minoxidil group showed superiority to the placebo group with respect to the following parameters at week 24: (1) non-vellus hair counts (p = 0.0084); (2) changes in non-vellus hair counts compared with baseline values (p = 0.0227), and (3) investigators' evaluations of hair growth (p = 0.019). There was no significant difference between minoxidil and placebo treatment with regard to blood pressure, pulse or weight changes. No serious side effects were reported during the study. The greatest number of medical events were dermatological in nature and mainly local and mild in intensity. From week 24 to week 48 all patients received active medication and showed further hair growth. At week 48 the investigators evaluated the new hair growth as moderate or dense in 32.7% of the patients. Our conclusion confirms previous reported studies according to which topical minoxidil seems to offer a safe and efficacious treatment for early male-pattern baldness in some patients. Further studies need to be done to characterize the most likely responders.

Administration, Cutaneous↗
PubMed1987

[Occupational eczema with photosensitivity caused by contact with Bryozoa].

Contact eczema to Bryozoa is a very invalidating fishermen's disease. Described in the North Sea ("Dogger Bank itch") and in the eastern Channel, it begins with the hands which have touched Bryozoa, these being microscopic "moss-like animals", unrelated to algae, which form coralliform, encrusting and filamentous colonies attached to the sea-floor. Sensitization results from handling nets (drag-nets and trammels) or, less frequently, fish trays. Bryozoa responsible for the disease are Alcyonidum hirsutum and, mostly, Alcyonidum gelatinosum. The case of occupational eczema presented here discloses two hitherto unrecognized allergens: another Bryozoa species, Electra pilosa, which proliferates in the early summer and forms encrusting colonies on various supports, and a sea-weed, Sargassum muticum, which up to now had not been held responsible for skin lesions. The summer outbreaks, from May to September, and the fact that the face and upper chest are involved are classically ascribed to the natural cycle of Bryozoa (colonies multiply in the warm season and regress in the winter) and to contact with uncovered parts of the body. The results of our photobiological exploration suggest that the distribution of the eczema might well be due to an additional photoallergic reaction.

Bryozoa↗
PubMed1987

[Multiple tumors of the follicular infundibulum with basocellular degeneration. Apropos of a case].

A progressive papular eruption on the face, limbs and vulva had been present for seven years in a 38-year old female patient. Some papules were small and confluent while others were sparse, as in nodular prurigo. Histology showed massive proliferation of the follicular sheath epithelium, connected to the lower surface of the epidermis. The lesion formed a plate-like area very similar to that observed in superficial basal cell carcinoma and corresponding to a tumour of the follicular infundibulum. Remarkable features of this case were the large number of lesions, their photosensitivity (they became pruriginous and increased in size after exposure to the sun), the presence of eccrine sweat glands beneath a skin lesion of the thigh, the basal cell degeneration of two lesions and the slight improvement observed after etretinate therapy. To our knowledge, such findings have not yet been reported in tumours of the follicular infundibulum.

Adult↗
PubMed1987

[Dosimetry of solar ultraviolet radiation. Daily and monthly changes in Paris].

The intensity of ultraviolet A and B radiations was measured in Paris (48 degrees North) by means of silicon photoelectric cells (Osram Centra dosimeter) from December, 1984 till February, 1986. The results, which must be regarded as approximate, are expressed as physical units (mW/cm2) and biological units (minimal erythema dose/hour). For sunny days two curves are presented separately for UVB and UVA: daily variations in radiation (hourly measurements) and daily variations at 11 hours (solar time) during one year. Maximum irradiation was observed at noon in early July: UVB 0.15 mW/cm2, UVA 5.4 mW/cm2. Between December and July the amount of UVB radiation was multiplied by 14 and that of UVA radiation by 9. For subjects with clear photo-type and when the sun was at its zenith, an MED per hour was obtained from May 1 onwards. Within a day, 30 p. 100 (summer) and 50 p. 100 (winter) of erythema-producing UV intensity were delivered between 11 and 13 hours (solar time). This kind of study has numerous clinical applications: advice regarding exposure to sun rays, dosing of heliotherapy, epidemiological data concerning photodermatitis (circumstances of exposure, UV threshold dose) and photocarcinogenesis (determination of annual MED doses in relation to areas of uncovered skin and occupational exposure to sun rays). Other studies on the French territory will provide a map of UV irradiation.

Paris↗
PubMed1986

[HLA typing in classical and African Kaposi's disease].

HLA A, B, C, typing have been done in 39 patients with clinically and histologically documented classical Kaposi's sarcoma. Thirty three were also typed for HLA DR antigens. Twenty seven were males, 12 were females and three ethnic groups were represented: european caucasoids 41%, north african caucasoids 38.5% and negroids 20.5%. The only statistically significant abnormality is an increase of HLA DR5 frequency (60.6 vs 26. p less than 0.001 et RR = 4.2). Such an increase has been evidenced also in AIDS patients, with or without Kaposi's sarcoma and then is not discriminant between all this different types of the disease.

Adolescent↗
PubMed1986

[Intravascular vegetating hemangioendothelioma].

In 1928, P. Masson described in hemorrhoids a peculiar lesions which he called "intravascular vegetating hemangioendothelioma". The possibility of cutaneous location of this lesion was demonstrated only in 1967. Rare if isolated, the intravascular vegetating hemangioendothelioma is often associated with other vascular lesions such as polyps, hemorrhoids, etc. Always benign, this tumor may be misdiagnosed as an angiosarcoma by inexperienced pathologists. In this article, three additional cases are described, the histological differences with an angiosarcoma are stressed and the pathogenesis of this lesion is discussed.

Adult↗