[Hla genotype and familial psoriasis].
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Biomedical subjects
Publications and source records attributed to J Civatte.
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Study of 29 cases of collodion baby and 169 cases previously published led to several conclusions. In the short-term, the child is threatened by pulmonary infections. The increased skin permeability may result in the loss of water or intoxication by cutaneous absorption of a substance applied to the skin. In the long-term the condition progresses to one of a congenital disturbances in keratinisation. In 2/3 of cases, the problem is that of congenital non-bullous ichthyosiform erythrodermia. Profression to lamellar ichthyosis, ichthyosis vulgaris, circumflex linear ichthyosos and Conradi's syndrome is established. Ichthyosis related to sex in our cases did not seem to be a feature of the collodion baby, the opinion in the literature being divergent. Congenital bullous ichthyosiform erythrodermia never begins as collodion baby syndrome.
For long, malignant melanoma of the skin was never treated other than surgically; in spite of considerable effort in this field, a large number of them remained with a very poor prognosis. In the severest cases, it was noted that the prognosis was little influenced by recent therapeutic progress. The latter, however, in the light of recent experience, seemed to justify the hope which was placed in it initially. The object of this report is to relate modern progress in the treatment based on clinical and pathological findings. It is the result of work undertaken during recent years by the research group on malignant melanomas of the Lariboisiére-Saint-Louis hospitals.
The authors studied 243 cases of patients with 269 muco-cutaneous localisations of Bowen's disease. After considering the aetiological factors, the various clinical signs and the pathological associations, they draw histological conclusions. Poikilocarynosis seems to be the most reliable histological sign. They conclude their study with the prognosis and treatment.
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A case of carcinomatous transformations of an intraepidermal epithelioma is presented by the authors. The rarity of this transformation is emphasized.
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