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Biomedical subjects

J Churg

Publications and source records attributed to J Churg.

At least 109 records · Page 6Linked to original sources
PubMed1973

Radiation nephritis. 3. Chemical, functional and morphologic correlates of the glomerular basement membrane.

In the rat, radiation injury to a kidney results in severe glomerular lesions, with only a moderate increase in proteinuria. The proteinuria, however, was found to be nonselective. There was no relationship between the degree and selectivity of the proteinuria. No change in the gross chemical composition of the glomerular basement membrane obtained from the irradiated kidney was observed when compared with the GBM of a) untreated control kidneys, b) kidneys obtained from sham operated rats, c) unilaterally nephrectomized and d) control kidneys of irradiated animals. In conclusion, no correlation could be established between the morphologic alterations of the glomerulus and the chemical or permeability characteristics of the membrane.

Amino Acids↗
PubMed1972

Phagocytic activity of the alveolar epithelial cells in pulmonary asbestosis.

In the course of pulmonary asbestosis in hamsters, alveolar epithelial cells can transform into large phagocytic cells which ingest asbestos fibers and produce asbestos bodies. In the process, the epithelial cells frequently lose their original Type I or Type II cell structure and change into a form intermediate between the epithelial cell and the alveolar macrophage. This transformation may be the result of continuous stimulation of the cells by repeated phagocytosis of asbestos, followed by rapid death of the host cell, release of the fibers and rephagocytosis by a new cell. It is suggested that some of the large macrophages in the alveolar spaces originate from the alveolar epithelial cells via the intermediate form.

Animals↗
PubMed1970

Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis.

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and alpha(2)-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.

Adolescent↗