Search PubMed⌕ Search

Biomedical subjects

J Chevrant-Breton

Publications and source records attributed to J Chevrant-Breton.

83 records · Page 5Linked to original sources
PubMedDate not supplied

[Hyperacute periarteritis nodosa complicating Basedow's disease].

The symptoms and the evolution of necrotizing vasculitis vary greatly. The authors illustrate the case of an 18 year old patient with a history of frequent allergic manifestations (urticaria and others) who was found to have, in septembre 1975, a typical case of Grave's disease. During the following 2 months she was treated with an iodide derivative. One year later the clinical signs increased to the point where a treatment associating lugol, carbamizole and propanolol was deemed necessary. Less than 2 months later there developed a polyvisceral disease with oscillating fever, polyarthralgia and necrotizing vasculitis. The plurivisceral nature of the illness was further illustrated by the presence of a hyperreflexia, a glomerulopathy and retinal exsudats. A muscle biopsy revealed the necrotizing vasculitis with granulomas typical of periarteritis nodosa. Cardiac, neurologic and renal complications were responsable for a rapid down-hill course and despite corticoïdes and immunosuppresive drugs, the patient died after a few weeks of treatment. That periarteritis nodosa should complicate the evolution of Grave's disease suggests a connection between the two, very probably immunologic in nature. The role of drugs capable of inducing vasculitis must be explored, especially the iodide derivatives, the antithyroïd medications or their association. Such cases, even though they may be rare, should incite special care in the prescription of antithyroïd drugs in the allergic patient.

Acute Disease↗
PubMedDate not supplied

[Pyoderma gangrenosum and chronic myeloïd leukemia. Two new cases (author's transl)].

Two new cases of pyoderma gangrenosum with chronic myeloid leukemia are described and added to three others of the literature. Pyoderma gangrenosum is often bullous, painful and progresses quickly. It seems to have a bad prognosis in myeloid leukemia as in polycythemia vera, in which it appears lately as an evolution to myelofibrosis or acute leukemia transformation. Chemotactic disorders of polynuclear may be the main etiological factor in these cases.

Adult↗
PubMedDate not supplied

[Evaluation of cardiovascular disturbances in patients with erythrodermic skin diseases by echocardiography (author's transl)].

Echocardiography was performed in seventeen patients with acute or chronic erythrodermic skin disease, to assess the cardiovascular disturbances. Fundamental difference is between the acute erythrodermic skin diseases, in which the cardiac output is low and the chronic erythrodermic skin diseases in which the cardiac output is very high, during the attacks. The reasons of this difference are studied. The ventricular function parameters are always normal and the hemodynamic disturbances seem only to be related to the modifications of the cardiac output induced by the erythrodermic skin diseases.

Acute Disease↗
PubMedDate not supplied

[A new case of Menkes syndrome. Prenatal exclusion diagnosis in a subsequent pregnancy].

Authors report the cases of a boy with a Menkes' disease which began by a convulsive encephalopathy at the age of two months with growth failure and metaphysical abnormalities. An oldest brother died at 2 years of age in an analogous scene. The diagnosis proved to be founded by the low serum copper and coeruleo-plasmia levels and by the increased uptake of copper in the cultured skin-fibroblasts. The hair was thin and kinky; microscopical study showed pili torti and trichorrhexis nodosa. For the following pregnancy of the mother, a prenatal diagnosis by precocious amniocentesis (amniotic fluid punction) allowed to say that the boy she was expecting for was clear of the disease because of the normal uptake of copper 64 Cu in cultured amniotic fluid cells of the foetus. Authors recall that Menkes' disease is a X linked recessive disorder beginning by epileptic seizure in the early months of life. The basic biochemical lesion of copper metabolism is unknown; there are abnormalities in copper and his binding protein (metallothionein) distribution with increased level is the kidney and decreased level in brain and liver. The copper therapy does not lead to clinical improvement. There is now a prenatal diagnosis: the study of copper uptake in cultured amniotic fluid cells of male fetus. It is abnormally increased in Menkes' disease.

Adult↗