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Biomedical subjects

J Chandler

Publications and source records attributed to J Chandler.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Validity of the Quality of Well-Being Scale for persons with human immunodeficiency virus infection. HNRC Group. HIV Neurobehavioral Research Center.

To evaluate the validity of the Quality of Well-Being Scale (QWB) for studies of patients with human immunodeficiency virus (HIV) disease, 514 men were studied who were divided among four categories: Centers for Disease Control and Prevention (CDC) Group A (N = 272), CDC-B (N = 81), CDC-C (N = 47), and uninfected male controls (N = 114). The QWB and a variety of medical, neuropsychological, and biochemical measures were administered to all participants. When QWB scores were broken down by HIV group, the CDC-C group was significantly lower (.614) than the CDC-B (.679), CDC-A (.754), or control group (.801). The difference between Groups CDC-C and CDC-A was about .14 units of well-being, which suggests that individuals lose 1/7 equivalents of 1 well year of life for each year they are in Group CDC-C in comparison to the asymptomatic group (Group CDC-A). In comparison to the controls, this would equal a 1-year of life loss for each seven infected individuals. The QWB was shown to be significantly associated with CD4+ lymphocytes (p < .001), clinician ratings of neuropsychological impairment (p < .04), neurologists ratings of dysfunction (p < .001), and all subscales of the Profile of Mood States. Baseline QWB scores were significant prospective predictors of death over a median follow-up time of 30 months. Multivariate models demonstrated high covariation between predictors of QWB. It was concluded that the QWB is a significant correlate of biological, neuropsychological, neurological, psychiatric, and mortality outcomes for male HIV-infected patients.

AIDS Dementia Complex↗
PubMedDate not supplied

The care of the veteran with a diagnosis of COPD: a focused review of medical practice patterns in six VA facilities.

This study is an example of the focused reviews performed within the VA's physician peer review program (MEDIPRO). Studies of this nature are conducted throughout the nation on the VA Medical District level. The study topics, criteria, data analysis and findings are the purview of the physician boards who are responsible for sharing study outcomes with district hospitals. The MEDIPRO process identifies strengths as well as opportunities for improvement and emphasizes educational approaches to resolving quality of care problems.

Data Collection↗