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Biomedical subjects

J Chakrabarti

Publications and source records attributed to J Chakrabarti.

At least 37 records · Page 2Linked to original sources
PubMed1997

In vivo cytogenetic studies on mice exposed to acesulfame-K--a non-nutritive sweetener.

Acesulfame-K, a sweetening agent, was evaluated in vivo for its genotoxic and clastogenic potentials. Swiss albino male mice were exposed to the compound by gavage. Bone marrow cells isolated from femora were analysed for chromosome aberrations. Doses of 15, 30, 60, 450, 1500 and 2250 mg of acesulfame-K/kg body weight induced a positive dose-dependent significant clastogenicity (trend test alpha < 0.05). These doses were within the no-toxic-effect levels (1.5-3 g/kg body weight in rats) reported by the Joint Expert Committee for Food Additives of the World Health Organization and the Food and Agriculture Organization of the United Nations. In view of the present significant in vivo mammalian genotoxicity data, acesulfame-K should be used with caution.

Administration, Oral↗
PubMed1995

Diagnostic evaluation of myocardial abscesses. A new look at an old problem.

A myocardial abscess is a life threatening complication of infective endocarditis that necessitates early diagnosis in order to identify the need for emergent surgical intervention and improved prognosis. This review discusses the relevant historical aspects, clinical features suggestive of the diagnosis, associated conditions and various appropriate imaging modalities--in particular, trans-thoracic and trans-esophageal echocardiography, Indium-111 radionucleide scintigraphy, and computerized tomographic scanning. Specific clinical and echocardiographic criteria for identifying a myocardial abscess are discussed and comparative data presented from published studies in the literature.

Abscess↗
PubMed1994

In vivo cytogenetic studies on mice exposed to natural food colourings.

Safflower Yellow and Kokum Red, two food colourings developed from natural plant products, were assessed in vivo for their clastogenic potential. Swiss albino male mice were exposed to the compounds through ip injections. Bone marrow cells isolated from femora were analysed for chromosome aberrations. The results show that the two food colourings were weakly clastogenic.

Animals↗
PubMed1992

Evaluation of pan masala for toxic effects on liver and other organs.

The acute and chronic oral toxicity of pan masala (betel quid without betel leaf) was assessed in gavage studies in rats. Clinical parameters (liver and serum glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and alkaline phosphatase) and organ weights were measured. The results indicate that chronic feeding of pan masala impaired liver function, as indicated by changes in enzyme activity, and decreased relative weights of the gonads and brain.

Animals↗
PubMed1992

Genotoxicity studies of the food additive ester gum.

Ester gum (EG) is used in citrus oil-based beverage flavourings as a weighting or colouring agent. In the present study, concentrations of 50, 100 and 150 mg/kg body weight were administered orally to male Swiss albino mice, and sister chromatid exchange and chromosomal aberration were used as the cytogenetic endpoints to determine the genotoxic and clastogenic potential of the food additive. Although EG was weakly clastogenic and could induce a marginal increase in sister chromatid exchange frequencies, it was not a potential health hazard at the doses tested.

Administration, Oral↗
PubMed1992

Endoluminal thermal occlusion of the ureter with the electromagnetic field-focusing device.

The authors attempted ureteral occlusion by means of heat application in nine ureters (24 sites) of New Zealand White rabbits with the electromagnetic field-focusing (EFF) device. The EFF device generates heat at the tip of a grounded probe by focusing eddy currents that have been induced within the tissues by an external radio-frequency field. The power settings were varied from 30 to 150 W. Heat was applied at multiple sites in each ureter. Immediate functional occlusion was seen in all nine ureters. Long-term complete occlusion was seen in six ureters at power settings ranging from 40 to 150 W, while long-term partial occlusion was seen in two ureters at 30-50 W. All sites at 30 W resulted in partial occlusions. Perforation of the ureter resulted in urinoma formation in one ureter at a site that was treated with 150 W. The EFF device can be used to endoluminally occlude the ureter by causing a fibrotic reaction to thermal injury. The effective power range for this application appears to be 40-100 W.

Animals↗
PubMed1991

Effect of 'Pan Masala' on the germ cells of male mice.

Cytogenetic analyses of meiotic metaphase I germ cells and abnormalities of head morphology of caudal sperms were conducted in male mice following oral feeding of Pan Masala. The substance was ground to a fine powder, dispersed in polysorbate solution and administered via gavage to the animals at 84, 420 and 840 mg/kg body weight at the rate of 10 ml/kg body weight. Polysorbate and cyclophosphamide served as the vehicle control and positive control respectively. The two higher doses, 420 and 840 mg, gave a significant increase in the frequency of X-Y univalents and breaks over those of the vehicle control. Frequency of sperm head abnormalities were significantly high for all the doses tested. The results indicate that Pan Masala is a potent clastogen, reaches the testes and affects the germinal cells.

Administration, Oral↗
PubMed1991

Surveillance of mercury content in edible fish.

Samples of estuarine/sea fish and prawn purchased from different markets in and around Calcutta were analysed for mercury content in the edible portions by cold vapour AAS. The contents varied widely from 4.5 to 42.4 ppb. The internationally regulatory fixed levels for mercury in fish (of 1.0 and 0.5 ppm) appear to be too high in view of our findings and the acceptable weekly intake of mercury of 0.005 mg/kg body weight. It is suggested that the statutory permitted level of mercury in fish be reduced drastically from 500 to 50 ppb.

Animals↗