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J Cervenka

Publications and source records attributed to J Cervenka.

208 records · Page 12Linked to original sources
PubMed1966

Tuberculin allergy in infants vaccinated with Czechoslovak, Danish or Swedish BCG vaccine.

It is well known that BCG vaccination in the newborn is particularly difficult to carry out with satisfactory results. The allergic response is delayed and weak in comparison with that in older children, and attempts to compensate for this by using a more potent vaccine often result in a high incidence of regional lymphadenitis. The preliminary results of a blind comparative trial, in newborn children, of BCG vaccine from Czechoslovakia. Denmark and Sweden are reported. There was no case of lymphadenitis in any of the three vaccine groups. The allergic reactions induced by the Danish and Swedish vaccines were of equal strength, although the vaccination scars from the Swedish vaccine were slightly larger. The vaccine from Czechoslovakia produced strikingly weaker allergic reactions as well as definitely smaller scars than the other two vaccines.

BCG Vaccine↗
PubMedDate not supplied

Effects of carbamazepine on human chromosomes.

The effect of carbamazepine (CBZ) on human chromosomes was studied in an effort to determine its mutagenic potential. Analysis of chromosome breakage, sister chromatid exchanges (SCE), and cell cycle studies were performed in peripheral lymphocyte cultures. The in vivo studies failed to detect any significant increase of chromosome aberrations or SCE or any slowing of the cell cycle. A significant dose-dependent increase in chromosome aberrations but not in SCE was observed in the in vitro analyses. No correlation was observed between chromosome breaks and SCE in either the in vivo or in vitro studies. The negative in vivo results indicate an absence of detectable chromosome-damaging effects of CBZ used in monotherapy in human subjects.

Adult↗
PubMedDate not supplied

Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk.

Appliers of pesticides (n = 18) who are exposed to the fumigant phosphine or who have a mixed exposure to other pesticides and phosphine demonstrate a significant increase in chromosome rearrangements in G-banded chromosomes from peripheral blood compared to control subjects (n = 26). Appliers who had discontinued using phosphine for at least 8 months prior to specimen collection (n = 5) do not demonstrate significant increases in chromosome rearrangements compared to controls. Breakpoint analysis of 6,138 metaphases from all subjects demonstrates 196 breaks per 3605 metaphases in exposed subjects and 102 breaks per 2,533 metaphases in control subjects. Bands with significantly more breaks than expected based on band length in all study subjects were 1q32, 3p14, 7p15, and 14q11. Three of these four bands had significantly more breaks than expected in the exposed group, and all four bands had a significant excess of breaks in the control group. There are four bands with a significant excess of breaks in the exposed group and no breaks in the control group; each of these occurs in a known protooncogene region. These are 1p13 (NRAS), 2p23 (NMYC), 14q32 (ELK2), and 21q12 (ETS-2). Most breaks at bands 1p13, 14q32, and 21q22 are associated with chromosome rearrangements and occurred in appliers who have a mixed exposure to phosphine and other pesticides. Cytogenetic abnormalities, i.e., rearrangements and/or deletions involving bands 1p13, 2p23, and 14q32, are associated with non-Hodgkin's lymphoma. We speculate that these findings could relate to the risk of evolution of a neoplastic clone in these workers. Epidemiological studies of similarly exposed workers indicate an excess of non-Hodgkin's lymphoma.

Chromatids↗