Biomedical subjects

J Cederholm

Publications and source records attributed to J Cederholm.

22 records · Page 2Linked to original sources

PubMed1985

Short-term treatment of glucose intolerance in middle-aged subjects by diet, exercise and sulfonylurea.

In a screening survey of women and men 47-54 years old for detection of glucose intolerance (GI), with 75 g oral glucose tolerance tests (OGTT), 25 subjects with GI were randomly selected for a therapeutic trial for normalization of the GI. A control group of 18 GI subjects was chosen randomly from the same health survey and given no treatment for 5-10 months; no significant changes in OGTT variables, body mass index, blood pressure or blood lipids were found in this group during follow-up. The treatment group was given advice concerning a low-sucrose, low-fat, high-fiber and energy-restricted (when overweight) diet and also concerning exercise - single-handed (16 subjects) or in an exercise group (9 subjects). The GI improved in the 25 treated subjects after 6 months of this therapy. Thus the total area under the glucose curve and the 1-h and the 2-h glucose values had decreased, the mean 2-h glucose value was restored to normal (less than 7.0 mmol X l-1) and 48% of the treated subjects had a normal 2-h glucose value. Body mass index, systolic blood pressure, serum cholesterol and serum triglycerides were also reduced at the follow-up. The 6-month result was similar in the subgroup of nine GI subjects who followed the dietary advice and exercised in a group for at least one hour per week during at least three months. Physical working capacity was increased, although non-significantly. Glipizide, 1.25 mg daily, was added at breakfast to ten GI-subjects who still had pathological 2-h glucose values after 6 months of dietary and exercise treatment. After a further 6 months of treatment of these 10 subjects, the total glucose area and the 2-h glucose value were reduced, while the mean 2-h glucose value had not required the normal level. Body mass index was unchanged. Another four subjects in this subgroup now showed a normal 2-h glucose value. In conclusion, the 2-h glucose value was restored to normal in totally 64% of all treated GI subjects after short-term treatment with a diet, exercise and, in some cases, added glipizide.

Blood Glucose↗

PubMed1985

Peripheral and autonomic nerve function in glucose intolerance.

In 19 middle aged subjects, glucose intolerant according to WHO criteria, obtained from a health survey, peripheral and autonomic nerve function were studied in comparison with 25 control subjects with normal glucose tolerance. Clinically detectable signs of peripheral nerve dysfunction were not more common in glucose intolerant subjects than in the control group. In measurements of sensory thresholds for vibration, nerve conduction velocities and autonomic nerve function, small differences, mainly non-significant, were found in favour of the controls. It is concluded that minor reduction of some peripheral nerve function may be associated with glucose intolerance, but it is not readily demonstrated. Clinically apparent polyneuropathy is not likely to develop.

Autonomic Nervous System↗

PubMed1984

Comparison of glycosylated hemoglobin with the oral glucose tolerance test. A study in subjects with normoglycemia, glucose intolerance and non-insulin-dependent diabetes mellitus.

At a health survey of 819 subjects, 47-54 years old, the rate of glucose intolerance (GI) was 6.2% (51 subjects) according to 75 g oral glucose tolerance tests (OGTT) and WHO criteria. In GI-subjects, the mean HbA1 was 7.3% (10th-90th percentile range 6.2-8.3%), and significantly higher than the mean HbA1 in 150 subjects with normal OGTT, which was 6.5% (10th-90th percentile range 5.7-7.4%). With an upper normal limit of 7.8% (mean + 2 SD) only 20% of all GI-subjects had a raised HbA1. The differences between 31 GI-subjects, with low HbA1 (mean 6.9%), and 20 GI-subjects, with relatively high HbA1 (mean 7.9%), were not significant with respect to fasting and 2-hour blood glucose, area under glucose curve, body mass index, index of physical activity, rate of hypertension or rate of first degree relatives with diabetes. In an unselected group of 157 subjects, sampled consecutively during the first part of the survey, the mean HbA1 was 6.6% (10th-90th percentile range 5.8-7.5 %) 150 subjects were those with normal OGTT, 6 subjects had GI and only one subject had previously unknown diabetes. No distinct correlations between HbA1 and OGTT fasting or 2 hour values were found in this sample. No correlation was found within the separate groups of 51 GI-subjects and 150 normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Glucose↗

PubMedDate not supplied

Impaired glucose tolerance: influence by environmental and hereditary factors.

The influence on impaired glucose tolerance (IGT) by obesity, physical leisure time activity (PLTA), family histories of diabetes mellitus (DM) and other characteristics were evaluated in a health survey of 807 middle-aged females and males, with the rate of IGT 8.4% (WHO-criteria). Independent (adjusted for covariates) odds ratios concerning IGT were estimated. The ratios were 5.3 with the presence of obesity and 2.2. (ns) with low compared to high PLTA. In a subgroup of summarized environmental factors (obesity and low PLTA versus no obesity and high PLTA, n = 339), the independent odds ratio for IGT was 9.6 with obesity and low PLTA. With one 1st degree DM relative the odds ratio for IGT was 3.1. The ratio was increased both with the presence of relatives with non-insulin-dependent diabetes mellitus and with the presence of relatives with insulin-treated diabetes. Diabetic mothers yielded a higher ratio for IGT than diabetic fathers. In conclusion, the independent relative risk for IGT in this Swedish middle-aged urban sample was about two times higher with environmental factors (obesity only/obesity with low PLTA) than with one 1st degree DM relative.

Diabetes Mellitus, Type 1↗