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Biomedical subjects

J Castellanos

Publications and source records attributed to J Castellanos.

At least 19 recordsLinked to original sources
PubMed1990

Effect of habitual knuckle cracking on hand function.

The relation of habitual knuckle cracking to osteoarthrosis with functional impairment of the hand has long been considered an old wives' tale without experimental support. The mechanical sequelae of knuckle cracking have been shown to produce the rapid release of energy in the form of sudden vibratory energy, much like the forces responsible for the destruction of hydraulic blades and ship propellers. To investigate the relation of habitual knuckle cracking to hand function 300 consecutive patients aged 45 years or above and without evidence of neuromuscular, inflammatory, or malignant disease were evaluated for the presence of habitual knuckle cracking and hand arthritis/dysfunction. The age and sex distribution of the patients (74 habitual knuckle crackers, 226 non-knuckle crackers) was similar. There was no increased preponderance of arthritis of the hand in either group; however, habitual knuckle crackers were more likely to have hand swelling and lower grip strength. Habitual knuckle cracking was associated with manual labour, biting of the nails, smoking, and drinking alcohol. It is concluded that habitual knuckle cracking results in functional hand impairment.

Aged↗
PubMed1989

Flexible fiberoptic rhinoscopy in the diagnosis of sinusitis.

Two-hundred forty-six patients with undiagnosed headache, after unrewarding neurologic evaluation, were referred to an allergy clinic and were evaluated both by routine sinus radiographs and flexible fiberoptic rhinoscopy. Ninety-eight patients had only rhinoscopic evidence of sinusitis (group I), 84 patients had both rhinoscopic and radiographic evidence of sinusitis (group II), and 64 patients had neither rhinoscopic nor radiographic evidence of sinusitis (group III). Antibiotic treatment resulted in relief of headaches in 94% of group I, 75% of group II, and 5% of group III patients. The distribution of sinus infections found by both rhinoscopy and radiography were similar; however, rhinoscopy may have found the disease earlier than radiography. Flexible fiberoptic rhinoscopy is an efficient method for the office diagnosis of sinusitis.

Adult↗
PubMed1988

Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group III, ex vivo flushing (10 min). All livers were then heterotopically transplanted into recipients, using the ILPM, by anastomosis of the portal vein, vena cava, and hepatic artery to the recipient's portal vein, iliac vein, and iliac artery. Reperfusion followed for 30 min. Laboratory samples collected at 0, 5, 15, and 30 min showed that hepatic function was not altered by ex vivo flushing and was only slightly altered by rapid in situ flushing. Regular in situ flushing proved to be damaging to livers. Histological analysis confirmed these findings. Therefore, either rapid in situ or ex vivo flushing can be safely used by the transplant specialist.

Adenosine Triphosphate↗
PubMed1986

Long-term treatment with captopril in paediatric patients with severe hypertension and chronic renal failure.

Forty two children with end stage renal failure and hypertension on chronic haemodialysis have been treated with captopril for from 18 to 78 months. Satisfactory control has been obtained in doses of 0.3 to 3.0 mg/kg given every 24 or 48 hours. Tolerance was good. The results of the present study suggest that captopril is a suitable drug for long-term use in paediatric patients.

Adolescent↗
PubMed1981

[Extramedullary plasmacytoma. Presentation of 3 cases].

The authors report three cases of extramedullary plasmacytoma, localized in the oral cavity, deltoid muscle and upper respiratory passages, respectively. The first case was followed for seven years until his death, the second case has been followed during nine years and is still alive and the third one is a recently diagnosed case.

Adenocarcinoma↗
PubMed1980

Hypothermic pulsatile perfusion: its use in the preservation of pancreases for 24 to 48 hours before islet cell transplantation.

Canine pancreases underwent hypothermic pulsatile perfusion for 24 or 48 hours before islet cell collagenase digestion and intrasplenic autotransplantation. The numbers of dogs surviving longer than two months are as follows: dogs receiving pancreatectomies, 0/10; dogs receiving 24-hour-perfused islet cells, 6/10, dogs receiving 48-hour-perfused islet cells, 4/10; and dogs receiving fresh islet cells, 7/10. Islet cells from 48-hour-perfused pancreases were not as good in reversing hyperglycemia as the islet cells from 24-hour-perfused pancreases. Histologically, the islet cells appeared to be normal in the fresh and 24-hour-perfused pancreases. Thus, hypothermic pulsatile perfusion of pancreas autografts for 24 hours appears to be a safe and reliable method. When this technique is used clinically, special attention should be given to 48-hour-perfused pancreases because the reversal of hyperglycemia sometime is not complete.

Amylases↗