Characterization of mitochondrial deoxyribonucleic acid from a series of petite yeast strains by deoxyribonucleic acid-deoxyribonucleic acid hybridization.
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Biomedical subjects
Publications and source records attributed to J Casey.
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The serum androgen response to physical exercise was studied in highly trained athletes and in normal male medical students. Serum androgens rose in response to maximal exercise and the rise was independent of serum luteinizing hormone. No response was obtained with submaximal exercise.
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Haemodialysis patients are at high risk of contracting Hepatitis B Virus (HBV). This blood borne virus has been responsible for many critical incidents within haemodialysis units around the world. This paper seeks to explore one such outbreak and at the same time look more closely at HBV and connected issues. The incident discussed occurred within a haemodialysis unit situated in the Northwest of England. This paper is presented as a case study. When HBV was detected in a previously HBV negative patient a crisis management team moved quickly to contain any possible outbreak and sought to discover the origin of the infection. An outline of the personal and financial cost to the organisation, what lessons have been learnt and why recommendations have been made to immunise the local dialysis population again HBV will be presented.
Renal Nursing presents many challenges for nurses seeking to work at advanced level. The ever-changing political climate and increasing service demands make it vital for nurses to grasp the opportunities that advanced practice offers. Theorists have suggested that the over-specialisation of nursing could lead to a fragmented nursing service and an undervaluing of the registered nurse. September 1999 saw the appointment of two such Advanced Nurse Practitioners within the renal unit. This article takes a personal look at the implementation of an Advanced Nurse Practitioner service over the first 12 months and suggests that such a role does have a lot to offer particularly in a renal setting.
Haemodialysis patients are subject to many restrictions and face a lifetime attempting to adhere to various regimes. This small study was designed to explore the relationship between fluid gain, compliance and staff reinforcement. This was achieved by measuring dietetic and nursing educational input using interdialytic weight gain as a barometer of patient compliance. This study suggests renal nurses, dietitians and other members of the multi-disciplinary team may have less influence than previously assumed.
European Best Practice Guidelines of 1999 for managing anaemia in patients with kidney failure state that patients using the subcutaneous route should be encouraged to self-administer epoetin whenever possible. This article argues for and substantiates the need to develop an education programme, which should consist of group and one-to-one teaching sessions with discussion, role-play, visual aids and demonstration. Information booklets will be provided covering blood pressure monitoring, ordering and storage of medication and safe disposal of syringes. Methods to evaluate the education programme include direct observation, laboratory reports, patient care plans and feedback. The theoretical benefits of such a programme should include; improved cardiovascular function with a more compliant patient enjoying an improved quality of life. The organisation should benefit through lower costs and a structured method of audit.
Advanced Nurse Practitioners (ANP) are developing their role in order to insert temporary and permanent central venous catheters to facilitate haemodialysis. Two hundred and eighty-nine central venous catheters (CVC) were inserted over a two-year period. The ANP inserted 117 CVC with 172 CVC inserted by the nephrology medical team. Using non-parametric independent two-group comparison Mann Whitney test and Chi-Squared test, the two groups were compared for specific outcomes. When comparing both groups with respect to CVC longevity, elective and non-elective removal along with infection (exit site and systemic) no statistical difference between the ANP and the nephrology medical staff could be found.
Urokinase and streptokinase are commonly used thrombolytic agents for obstructed central venous catheters. Although proven to be efficacious, these agents have the potential to induce fibrin breakdown and streptokinase cannot be used repeatedly due to its allergenic nature. Documented evidence suggests that urokinase is safe and effective (> 70% efficacy for catheter installation) however further evidence points to tissue-type plasminogen activator (rt-PA) achieving as much as 98% success. This study reports on the safety and efficacy of alternative catheter thrombolysis, namely rt-PA and evaluates the efficacy of rt-PA. 20 patients required 57 infusions in 38 lumens between 01/01/02 to 01/09/03. For completely blocked lines rt-PA was infused at 2 mg/hr for 4 hours achieving 85% success rate. For inadequate flow (< 250 mls/min) rt-PA was infused at 1 mg/hr for 4 hours achieving 88% success rate.
Diabetes is the leading cause of end-stage renal disease in the western world and significant proportions of patients with diabetes mellitus develop renal complications. Anaemia is a key indicator of renal disease, and potentially may contribute to the pathogenesis of diabetes complications. Early correction of anaemia therefore has the potential to prevent or reverse other complications This review of the literature will examine anaemia in diabetic patients and seek to determine whether it is exclusive to diabetic nephropathy.
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