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Biomedical subjects

J Caron

Publications and source records attributed to J Caron.

At least 109 records · Page 6Linked to original sources
PubMed1976

[Progressive exhaustion of the psychotropic effect of T.R.H. Clinical and neuroendocrinologic study].

The progressive exhaustion of the psychotropic effect of T.R.H. clinical and neuroendocrinological study. The study of a complicated clinical case permitted us to use T.R.H. because of the ineffectiveness of other psychotropic agents the patient (male, aged 38) was given previously. A major and atypical depressive state with severe anorexia was lasting from several months. T.R.H. was administered 3 times per day (at 8 h. 11 h and 14 h) as an intravenous injection of 0.5 mg of T.R.H. lasting 1 min. (total dose per day: 1.5 mg). From the 1st to 7th day the patient showed a market improvement) in the depression symptoms, followed by a light degradation observed from the 7th to 10th day. During a third phase, he showed wild improvement which was maintened stable from the 10th to the 21st day. Then, there was a progressive return to the state prior to T.R.H. period till the 30th day. This phase lasted up to the end of the therapeutic trial of T.R.H. These fluctuations of the depressive state were not found to be correalted with significant plasma-T.R.H. changes and seem to happen when changes in catecholamines and/or serotonin were not observed, according to methods used. Independently of various theoritical approaches concerning the mechanism of psychotropic T.R.H. action, it seems that its effect is exhausted progressively and rapidly.

Adult↗
PubMed1975

[A multidisciplinary study of infantile Steinert's syndrome].

The authors studied from several points of view 10 patients suffering from a neo-natal form of Steinert's disease. They analyse the variety of the family histories, of dysembryoplastic symptoms, of neo-natal difficulties and the subsequent impairment of mental development. They could not find any correlation between this latter evolution and the severity of the neurological damage, judged by the mentioned symptoms. They conclude that the mental retardation is proportional to the low quality of the early socio-emotional environment and believe that this hypothesis is confirmed by the fact that maxillo-facial malformations are mocise speech and mimicry in their early childhood.

Female↗