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Biomedical subjects

J Caroff

Publications and source records attributed to J Caroff.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Kinetics of prolactinemia after withdrawal of dopamine perfusion and during the administration of domperidone. Normal and hyperprolactinemic subjects (prolactinomas and suprahypophyseal lesions)].

Fifteen normal menstruating women in the early follicular phase of their menstrual cycle, fifteen patients with prolactin secreting adenomas, two patients with a suprahypophysial lesion and an hyperprolactinemia, underwent a dopamine infusion (4 micrograms/kg/mn for four hours and an orally administration of domperidone (40 mg). Prolactin rebound after the arrest of dopamine infusion and during domperidone are + 400% and + 2,300% in normal subjects. These same studies are followed by similar and reduced prolactin response in suprahypophyseal lesion and prolactinomas. Such results suggest an abnormality of central dopaminergic control and/or a primary abnormality of lactotropes in prolactinomas. In two prolactinomas the normalization of both prolactin level and prolactin responses during the same tests is in favor of a primary abnormality of adenomatous lactotrope. These data justify neuro-surgical adenomectomy.

Adenoma↗
PubMed1983

[25-hydroxyvitamin D plasma levels in adults, neonates and their mothers].

25-hydroxyvitamin D (25 OH vit D) plasma levels were measured according to the method of Preece et al. in 2 groups of subjects. Group 1 consisted of 10 adult controls in whom 25 OH vit D levels were measured 11 times at 1 month intervals. Group 2 consisted of 93 mother-child pairs including 71 neonates with normal plasma calcium levels (group 2a) and 22 with hypocalcemia (group 2b). In mothers, 25 OH vit D levels (group 2a: 12 ng/ml +/- 6.4 SD, n = 71; group 2b: 9.5 ng/ml +/- 3.5 SD, n = 22) were lower than in controls (25.1 ng/ml +/- 7.9 SD). In neonates, 25 OH vit D levels were correlated with those of their mothers; however there was no significant difference in neonates with or without hypocalcemia (group 2a: means = 11.9 ng/ml +/- 6.1 SD, n = 71; group 2b: means = 10 ng/ml +/- 4.1 SD, n = 22). 25 OH vit D levels in adults of group 1 were significantly correlated with exposure to sunlight, while no significant correlation was found in the mothers-children pairs of group 2. These results confirm the relationship of 25 OH vit D plasma levels of neonates with their mothers' but do not support the concept of a relation between low plasma levels in mother and the occurrence of hypocalcemia in neonates.

Adolescent↗
PubMed1981

[Domperidone: a new pharmacodynamic agent for exploration of the hypophysis (author's transl)].

Domperidone is a peripheral antagonist of dopamine which does not cross the blood-brain barrier. It is administered orally in doses of 40 mg and consistently induces a rise in prolactin (delta + 2500 % at 90 minutes; surface under the curve 306,000) on condition that the mammotropic cells are in sufficient numbers and under central dopamine control. Adenomatous mammotrophs do not respond to domperidone (p less than 0.001 difference with controls). Three months after transphenoidal adenomectomy and correction of hyperprolactinaemia, there was no significantly change in the kinetics of prolactin response to the product. Some gonadotrophic hormone-producing adenomas exhibit paradoxical response of GH to L-dopa and domperidone, which disappears after surgical excision.

Benzimidazoles↗
PubMed1979

[Female hyperprolactinaemia. 19 cases (author's transl)].

The authors were able to confirm the ineffectiveness of vitamin B6. The correction of hyperprolactinaemia by bromocriptine restored ovarian function immediately, or after the failure of surgical treatment. It would still be premature to determine the exact place of surgery in this type of pathology.

Adolescent↗
PubMed1978

[Hypogonadotrophic hypogonadism. Pituitary and testicular reactivity--receptivity to androgens (author's transl)].

Six subjects aged between 19 and 29 years were studied. Gonadotrophins, follicular stimulating hormone or FSH and luteotrophic hormone or LH, were low in all cases. Under the influence of a single dose of 150 microgram of hypothalamic gonadotrophin liberation factor (LHRH), there was a preferential increase in FSH whilst levels of LH were little influenced. The continuous infusion of LHRH was associated with the same phenomenon. Only prolonged administration (for approximately 12 months) of chorionic gonadotrophins, resultes in a significant rise in plasma testosterone levels (low in all cases in the absence of stimulation). The level of urinary 3alpha-androstanediol represents a good parameter of androgenicity. Urinary 3beta-androstanediol is a metabolite of androgens formed in the liver. In hypogonadotrophic hypogonadism, and in particular in de Morsier's syndrome, the essential element would seem to be the absence of solicitation of the pituitary gonadotrophic cells by virtue of inadequate secretion of LHRH. The results of stimulation with chorionic gonadotrophins reflects the existence of inadequate maturation of testicular receptors to these hormones.

Follicle Stimulating Hormone↗
PubMed1975

[Evaluation of the parietal factor interfering in the measurement of cardiac output by external detection with the aid of 99mTc labelled red cells (author's transl)].

The results of a radioisotopic exploration are not independant of the physical characteristics of the tracer used. Thus in the measurement of cardiac output index by external detection, the substitution of 131I fastened on the human serum albumine by 99mTc fastened on red cells introduces a systematic average error of +20% whose origin is double. Because of the plasma or red cell kind of the tracer, the average error done on the volume is, in 130 measurements, 26% whereas that which results from the difference of photon energy is -6%. Only this last error affects the measurement of the cardiac output and, by that time, it is demonstrated that a direct determination of the cardiac output index by STEWART-HAMILTON'S relation is impossible.

Cardiac Output↗
PubMed1975

[Estimate of coronary blood flow by simple fixation measurement of 86Rb on the cardiac muscle (author's transl)].

The method for measuring coronary blood flow, which is described here, is based on the estimate, by external detection, of the quantity of 86Rb fastened on the cardiac muscle about ten minutes after the injection. The discussion which follows after this report, shows that the use of such a late time for the measurements does not contradict the fondamental hypothesis but allows to work in perfect technical conditions. The results obtained,widely superposable to those which have been published until to-day, prove a posteriori the availability of the method.

Coronary Circulation↗