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Biomedical subjects

J Carlier

Publications and source records attributed to J Carlier.

At least 55 records · Page 3Linked to original sources
PubMed1982

Pharmacokinetics of mexiletine in renal insufficiency.

1 The aim of this study was to evaluate the influence of renal insufficiency on the plasma pharmacokinetics of mexiletine, a new antiarrhythmic agent, in human beings. 2 Mexiletine was administered orally three times daily for 10 days to 15 patients with chronic renal failure (creatinine clearance lower than 30 ml/min) and to 9 subjects with normal renal function. 3 The use of low doses of mexiletine was possible owing to the development of a new fluorescence h.p.l.c. method with a limit of sensitivity lower than 20 gn/ml. 4 Our results clearly indicate that the plasma kinetics of mexiletine are not modified when the renal clearance of creatinine is higher than 10 ml/min.

Aged↗
PubMed1980

Mexiletine in the treatment of ventricular arrhythmias.

The effect of mexiletine, a new antiarrhythmic drug, was studied by oral (600 to 1200 mg/day) or intravenous (250 mg in 10 minutes) route in 45 patients; most of them had coronary insufficiency. Our results show that mexiletine is a potent ventricular antiarrhythmic drug which is efficient on several types of xylocaine resistant ventricular arrhythmias. In our experience, mexiletine is reliable when administered intravenously; there are frequent and sometimes severe side-effects when given orally.

Administration, Oral↗
PubMed1980

Pharmacokinetics of mexiletine in renal insufficiency.

Mexiletine (Mexitil) is an effective antiarrhythmic drug for the treatment of ventricular dysrhythmias. The therapeutic plasma level is situated between 0.75 and 2 microgram/ml. For concentrations higher than 2 microgram/ml, the percentage of severe side effects is rapidly increasing without improvement of the therapeutic efficacy. The main pharmacokinetics parameters of mexiletine are reviewed in the first part of this publication. Contrary to lidocaine, mexiletine may be administrated orally (or intravenously). It is largely and rapidly distributed in the body. The apparent volume of distribution (Vd) is greater than 500 1. The plasma half-time is 10 to 12 hours in healthy volunteers with a 70% plasma protein fixation. Mexiletine is largely metabolized to conjugates after N-methylation and hydroxylation. In the second part of the work, the influence of renal insufficiency on the plasma half-time of mexiletine has been investigated in 11 patients presenting a creatinine clearance situated between 2 and 38 ml/min. The mean plasma half-time for these patients is 11.1 +/- 1.7 hours after a single i.v. injection of 1.5 mg/kg. This value is comparable to the normal values found in the literature. Our control group containing convalescents from acute myocardial infarct has a plasma half-time of only 5.9 hours. In conclusion, the renal insufficiency has not modified the plasma elimination half-time of mexiletine after a single i.v. injection.

Administration, Oral↗
PubMed1980

Hemodynamic, electrocardiographic and toxic effects of the intravenous administration of increasing doses of mexiletine in the dog. Comparison with similar effects produced by other antiarrhythmics.

The hemodynamic and electrocardiographic effects of intravenous injections of mexiletine in progressively increased doses, starting from 1.5 and 3 mg, have been studied in two series of 8 and 6 dogs anaesthetized with pentobarbital. The analysis of the results showed that absence of change in aortic pressure, heart rate and output when the minimal doses are injected, is due to the interaction of opposite effects: a direct depressing effect on the myocardial contractility, and a sympathic reflex stimulation secondary to a peripheral vasodilation. The comparison of hemodynamic, electrocardiographic and toxic effects of mexiletine with those produced by other antiarrhythmics showed that mexiletine placed itself among the better tolerated antiarrhythmics during the administration of progressively increasing doses.

Ajmaline↗