Biomedical subjects
Publications and source records attributed to J Careaga Maldonado.
A boy with severe symptoms of biotinidase deficiency diagnosed at the age of 12 years showed a remarkable improvement of his neurological picture and normalization of brain magnetic resonance imaging abnormalities when prescribed oral biotin.
During 18 months 100 children were submitted to a longitudinal study, in order to compare the efficacy of treatment with administration of intermittent rectal diazepam versus oral BID phenobarbital therapy, for prevention of febrile seizures. The group was divide in a randomized trial. Rectal diazepam was administered at dose os 0.5 mg/kg dose and the dose was repeated every eight hours during the period of fever. Diazepam was found to be as effective as oral phenobarbital in the prevention of new febrile seizures.
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