[The sick physician].
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Attitude to Death↗
Biomedical subjects
J Canals Cadafalch
Publications and source records attributed to J Canals Cadafalch.
[Hepatic adenomas and oral contraceptives. Report of two cases and review of the literature (author's transl)].
The authors report two cases of benign liver tumors which were histopathologically diagnosed as liver adenomas. Both patients had a former history of taking oral contraceptives. The authors carry out a critical review of the literature up until the present day and evaluate the data which exist for and against the relationship between oral contraceptives and hepatic tumors. These are based mainly on suggestive clinical observations and on experimental studies with animals, and also on the structural affinity of oral contraceptives with androgen compounds. The latter are drugs that are very much implicated in the genesis of hepatic tumors. A criticism is made on the terminology used, from a histological point of view, to describe the tumor lesions that are related to oral contraceptives; the presence of dilated vessels with find walls and the existence of hepatic peliosis inside of such tumors are emphasized. The clinical presentation of these tumors is reviewed very briefly and the authors conclude that oral contraceptives have a close relationship with the appearance of liver tumors, either inducing them directly, or at least, helping them to grow.
Adenoma↗
[Bird breeder's lung in children].
A case of hypersensitivity pneumonitis due to pigeon-dropping antigens is reported in a 9 year old girl, and compared with other seven previous reports in children. The insidious nature of this disease, as well as the importance of detailed environmental information in children with unexplained respiratory disease are emphasized. In this case, lung function tests showed a classic restrictive ventilatory defect, and a serious obstructive ventilatory defect evidenced in the narrowing of the smaller airways, and a reduction in the forced expiratory flow at small lung volumes. Hypersensitivity pneumonitis is a lung disease that results from sensitization by inhalation of a variety of organic dusts. Patients usually have circulating antibodies against the etiologic agents. Most patients with this disease also have sensitized T-cells to these agents. Long-term exposure can lead to irreversible lung disease. The histopathologic features are chronic interstitial and alveolar inflammation frequently accompanied by a granulomatous response. The most common symptomatic features are fever, chills and dyspnea 4 to 8 hours after exposure. Antibody activity to antigens is detected in the serum of both symptomatic and asymptomatic breeder's lung. Cellular hypersensitivity to antigens is demonstrated "in vitro" with peripheral lymphocyte populations in almost all symptomatic patients.
Airway Obstruction↗