Biomedical subjects
Publications and source records attributed to J Calap.
The authors comment the interest of the X Ray microanalysis in Dermatology and, especially, the Cu/Zn index determination in cutaneous tumors.
A case of epidermolysis bullosa acquisita (EBA) in a 64 year old man is reported. The direct immunofluorescence showed a positive lineal anti IgG basement membrane on the affected skin (blisters and provocation tests) and on the univolved healthy skin. The electron microscopic studies showed a "dermolysis". In this patient it was not possible to find any pathological association. The EBA is usually associated with different processus but, sometimes, it could be isolated. Probably this clinicopathological field includes diverse badly delimited entities.
A skin biopsy of a 37 year old man with typical lesions of pseudoxanthoma elasticum (P.E.) associated with angioid streaks (Groenbald-Strandberg Syndrom) was examined with a scanning E.M. (SEM) and a SEM provided with a X ray micro-analyser. The SEM provided with X ray microanalyser enabled us to see the correspondence between the crystalline deposits and a calcium salt. The potassium, sodium and magnesium analysis of the specimen permits us to verify that the P.E. dermis is rich in K and poor in Mg.
A skin biopsy a 37 year old man with typical lesion of pseudoxanthoma elasticum associated with angioid striae (Groenblad-Strandberg syndrome) was examined with a scanning EM (SSM-2A) and a scanning EM provided with a X ray microanalyser. With the scanning EM (SSM-SA) it was possible to see tabular crystalline deposits with subround faces and rhombohedric tendency. The scanning EM provided with a X ray microanaliser enabled us to see crystalline deposits which in some fields adopt a star-shaped form corresponding to calcium crystals of not very well defined habit. The X ray microanalyser shows us the correspondence between the star shaped figures and a calcium salt. The potassium, sodium and magnesium analysis of the specimen permits us to verify that the pseudoxanthoma elasticum dermis is rich in K and poor in Mg.
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