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Biomedical subjects

J Caen

Publications and source records attributed to J Caen.

At least 109 records · Page 6Linked to original sources
PubMed1975

[Platelet membrane glycoprotein defect, molecular basis for the abnormal adhesion of platelets to the subendothelium in thrombocytic hemorrhagic dystrophy].

A large reduction in the staining capacity of a glycoprotein of 155 000 M.W. was observed in the platelets of 2 macrogiant platelets syndrome patients, associated with a reduced platelet adhesion to rabbit aorta subendothelium and with the presence of von Willebrand protein on these platelets as revealed by an antihuman factor VIII-Von Willebrand protein rabbit antibody. These results led the authors to propose a strong hypothesis on the role of this glycoprotein rich in sialic acid - in platelet adhesion to subendothelium.

Adult↗
PubMed1975

Platelet hyperaggregation and increased plasma level of Von Willebrand factor in diabetics with retinopathy.

In 18 insulin-dependent diabetics (6 without retinopathy, 6 with proliferative retinopathy and 6 with proliferative retinopathy treated by hypophysectomy) matched for age and duration of diabetics, in vitro haemostasis was studied using ADP induced platelet aggregation, ristocetin induced platelet aggregation which allows von Willebrand factor (VIII VWF) assay, and determination of antihemophilic factor procoagulant activity (VII AHF). Using gel filtration-isolated platelets, the ADP induced hyperaggregation previously reported in diabetics with severe retinopathy untreated by hypophysectomy appeared to be related to a platelet and not a plasma factor; the normal results of thrombin induced aggregation suggests that the presumed abnormal platelet factor is related to the platelet plasma membrane. High level of plasma VII VWF was observed in diabetics with proliferative retinopathy while the VII AHF level was within normal limits.

Adenosine Diphosphate↗
PubMed1972

[Bleeding time].

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Afibrinogenemia↗