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Biomedical subjects

J C Wright

Publications and source records attributed to J C Wright.

At least 163 records · Page 9Linked to original sources
PubMed1977

A comparison between volunteer drug-abusers and non-drug-abusers on measures of social skills.

This study assessed specific behavior patterns of volunteering "had" drug-abusers in comparison to non-drug-abusers on self-report and behavioral measures of social skills. It was hypothesized that the individual's behavior is affected both by his group affiliation and by the immediate situational variables. Twelve drug-abusers and 12 university students were asked to interact with trained role-players in simulated social situations geared to elicit assertiveness and heterosexual dating behaviors. Task requirements as well as environmental social consequences (role-player's responses) were manipulated. Contingent on the situation type, both groups demonstrated basically the same level of social efficiency on verbal measures, but showed different performances on nonverbal measures. Preferential social interaction responses were found to be affected by the varied environmental feedback. The relevance of an "interactionist" approach to research on drug abuse and some crucial methodological factors are discussed.

Adolescent↗
PubMed1977

An in-training assessment examination in family medicine: report of a pilot project.

A family medicine in-training assessment examination was developed and piloted in 20 programs across the country. Core Content Review questions were used for the examination. Reporting of scores used both the traditional, normative-referenced approach, and a criterion-referenced approach. The latter permitted family medicine faculty to set passing standards for the examination. The pilot project was well received and the examination will be offered to all family medicine residency programs this year.

Connecticut↗
PubMed1977

Profile of full-time family practice educators.

This paper presents the first study of characteristics of full-time family practice educators in the United States. The majority of family practice educators entered the teaching field within the 1972 to 1975 time period, having done so after a period of ten to 20 years in the private practice of family medicine. Group practice (124) marginally outnumbered solo practice (102) with internal medicine and pediatrics representing the greatest percentage of patient care in all previous practice settings. A large majority of family practice educators have had two years of graduate training and are diplomates of the American Board of Family Practice. The respondents expressed a high degree of personal and professional satisfaction in their present positions, but many desired continuation of personal patient contact.

Adult↗
PubMed1976

Pseudohypoaldosteronism due to sweat gland dysfunction.

Pseudohypoaldosteronism is an uncommon disorder characterized by urinary sodium wasting and is attributed to a defect in distal renal tubular sodium handling with failure to respond to endogenous aldosterone. Sweat electrolyte values in other reported patients, when measured, have been normal. A 3.5-year-old girl developed repeated episodes of dehydration, hyponatremia, and hyperkalemia during the first 19 months of life. Serum sodium was as low as 113 mEq/liter and potassium as high as 11.1 mEq/liter. Her plasma and urinary aldosterone levels were persistently elevated (Figs. 1-4). Unlike patients with classic pseudohypoaldosteronism she demonstrated no urinary sodium wasting (Figs. 2 and 3). During episodes of hyponatremia and reduced sodium intake her urinary sodium was less than 5 mEq/liter. In addition, her sweat sodium concentration was consistently above 125 mEq/liter and salivary sodium concentration above 58 mEq/liter. Her chest x-ray, 72-hr fecal fat excretion, serum and urinary pancreatic amylase (amy-2) were normal, providing no evidence for cystic fibrosis. It is proposed that this patient represents a new variant of pseudohypoaldosteronism with excessive loss of sodium from the sweat and salivary glands instead of the kidneys.

Aldosterone↗
PubMed1975

A predictive test for the selection of cancer chemotherapeutic agents for the treatment of human cancer.

The use of animals for the screening of chemotherapeutic agents effective against cancer is not always satisfactory. In addition to the problems of cost, space, and care, the results obtained by animal screening do not always parallel those obtained by the clinical use of the agents. With the advent of more refined in vitro technics which can be applied directly to the patient's own tumor tissue, additional information may permit a more critical evaluation of the laboratory findings. The critical index of sensitivity probably lies in the combined evaluation of biochemical analysis and observed morphological damage. From this investigation it would appear that tissue culture of human tumors may serve as a valuable adjunctive method for the screening of chemicals in order to find drugs valuable in the treatment of cancer in man and to serve as a method in the selection of the most effective therapeutic agent for a given tumor in a given patient.

Antineoplastic Agents↗