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Biomedical subjects

J C Wright

Publications and source records attributed to J C Wright.

192 records · Page 11Linked to original sources

A retrospective study of canine hip dysplasia in 116 military working dogs. Part I: Angle measurements and orthopedic foundation for animals (OFA) grading.

The progression of hip dysplasia was investigated in 116 military working dogs. Serial pelvic radiographs were graded for degree of dysplasia and degenerative joint disease (DJD). Norberg angles, angles of inclination, and joint space widths were measured. There was a significant correlation between the Norberg angle and the degree of dysplasia (p less than 0.0001). Angles of inclination and joint space width measurements did not demonstrate a correlation to canine hip dysplasia. Dysplastic dogs had a significant estimated risk for development of DJD compared to normal dogs (p less than 0.0001; odds ratio of 70.2). Dogs with normal hip conformation at 24 months of age or older did not develop moderate nor severe DJD.

Animals↗

A retrospective study of canine hip dysplasia in 116 military working dogs. Part II: Clinical signs and performance data.

The progression of hip dysplasia was investigated in 116 military working dogs. Medical records were reviewed for any clinical history of hind-limb lameness. Pelvic radiographs were studied for evidence and degree of hip dysplasia, degenerative joint disease, or both. The number of months each dog worked was determined. Each dog's age at termination from service and cause of death (or euthanasia) were recorded. The mean months of work for normal and dysplastic dogs were evaluated using the Student's t-test. No significant difference was found in the total number of months worked between normal and dysplastic dogs (p greater than 0.05).

Animals↗

Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985-1999).

A retrospective study was performed of 17 dogs and seven cats with various stages of thymoma treated with radiation alone or as an adjunctive therapy. Analysis revealed an overall response rate of 75% (15/20 evaluable cases). Partial (i.e., >50% reduction in tumor size) and complete (i.e., no detectable tumor) responses were included. Complete responses were rare (4/20). Three of five animals with stable disease (i.e., <50% change in tumor size) had improvements in clinical signs, despite lack of measurable response. A median survival time of 248 days (range, 93 to 1,657+ days) was achieved in dogs, and a median survival time of 720 days (range, 485 to 1,825+ days) was achieved in cats. Radiation therapy appears to be useful in the management of invasive thymomas in dogs and cats.

Animals↗

Evaluation of chicken infectious anemia virus and associated risk factors with disease and production losses in broilers.

A case-control study was performed to determine the significance of chicken infectious anemia virus (CIAV) as a risk factor associated with secondary disease in commercial broilers and to identify the significance of production losses associated with CIAV. The study also examined the relationship between bursal and thymic atrophy and the presence of CIAV. Cases were defined as submissions to the Alabama Veterinary Diagnostic Laboratories with a history of clinical disease and with a diagnosis of coccidiosis, gangrenous dermatitis, or respiratory disease. Controls were selected from submissions with neither a history of disease nor evidence of disease on necropsy. CIAV was detected in fresh tissues by polymerase chain reaction. Both thymic atrophy and the detection of CIAV were significantly associated with a disease case (P < 0.05). Bursal atrophy was a significant risk factor associated with the detection of CIAV in a submission (P < 0.05). Whereas CIAV was associated with disease cases that showed production losses in both percentage of livability and percentage of condemnations (P < 0.05), detection of CIAV alone was not associated with detectable losses in production or flock performance.

Agriculture↗

Reported cat bites in Dallas: characteristics of the cats, the victims, and the attack events.

Associated with the increased popularity of cats as pets in American households has been an increase in the number of cat bites reported to health departments. Bite reports from Dallas, TX, for 1985 were analyzed for different aspects of the cat bite event, including characteristics of the cats, the people bitten, the wounds, and the attack events. Cat bites and scratches constituted 25 percent of the 2,494 reported animal bites. Biting cats were typically stray females. People 21 to 35 years old were bitten in numbers disproportionate to their numbers in the Dallas population. Females were the victims of a majority of bites. Although wounds were typically described as "scratches" of a hand or finger, 80 percent of all victims sought some form of treatment for their wound. The highest proportion of bites occurred from May through August from 9 am through 12 noon; unowned cats accounted for most wounds. Cat bit events may be explained by frequency of contact, that is, women prefer cats as pets; activities that bring people and cats into contact; and reaching toward cats to feed or pet them. More specific information on the causes of cat bites will enable educational programs to be established so that the rate of cat bites can be decreased at the community level.

Adolescent↗

Vaginal birth after cesarean section in a community hospital: a family practice residency experience.

Several tertiary care, multicenter studies have shown vaginal birth after Cesarean section (VBAC) to be a viable alternative in a select patient population. The premise of our study was that VBAC is a safe option in a community hospital setting. Any patient meeting the criteria of the American College of Obstetricians and Gynecologists (ACOG) was eligible for a trial of labor, and ACOG guidelines regarding mandatory facilities and personnel were followed. One hundred six women with a history of previous Cesarean section were delivered of infants during the study period. Of these, 16 attempted a trial of labor, and 13 (81.3 percent) had vaginal births with minimum morbidity. There were no instances of scar disruption. Thirty-nine percent of the patients who were successful with VBAC had had a previous vaginal birth. By offering VBAC, the participating physicians were able to reduce their repeat Cesarean section rate by 12 percent.

Adult↗

Severe attacks by dogs: characteristics of the dogs, the victims, and the attack settings.

Sixteen incidents involving dog bites fitting the description "severe" were identified among 5,711 dog bite incidents reported to health departments in five South Carolina counties (population 750,912 in 1980) between July 1, 1979, and June 30, 1982. A "severe" attack was defined as one in which the dog "repeatedly bit or vigorously shook its victim, and the victim or the person intervening had extreme difficulty terminating the attack." Information from health department records was clarified by interviews with animal control officers, health and police officials, and persons with firsthand knowledge of the events. Investigation disclosed that the dogs involved in the 16 severe attacks were reproductively intact males. The median age of the dogs was 3 years. A majority of the attacks were by American Staffordshire terriers, St. Bernards, and cocker spaniels. Ten of the dogs had been aggressive toward people or other dogs before the incident that was investigated. Ten of the 16 victims of severe attacks were 10 years of age or younger; the median age of all 16 victims was 8 years. Twelve of the victims either were members of the family that owned the attacking dog or had had contact with the dog before the attack. Eleven of the victims were bitten on the head, neck, or shoulders. In 88 percent of the cases, the attacks took place in the owner's yard or home, or in the adjoining yard. In 10 of the 16 incidents, members of the victims' families witnessed the attacks. The characteristics of these attacks, only one of which proved fatal, were similar in many respects to those that have been reported for other dog bite incidents that resulted in fatalities. On the basis of this study, the author estimates that a risk of 2 fatalities per 1,000 reported dog bites may exist nationwide. Suggestions made for the prevention of severe attacks focus on changing the behavior of both potential canine attackers and potential victims.

Adolescent↗

Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin.

Five clonal cell lines were established from each of 3 cell lines derived from 3 primary malignant canine mammary tumors. The clonal lines in each series were compared with one another and to the respective parent cell line with regard to cellular morphology, growth on plastic, cloning efficiency (CE) and colony sizes in soft agar, estrogen and progesterone receptor (ER, PR) status, and response to tamoxifen or doxorubicin in clonogenic assays. The most remarkable differences observed among the cell lines were in CE, colony sizes, and sensitivity to doxorubicin. The clonal line which contained measurable ER, had a shift in colony-size distribution to smaller colonies when exposed to tamoxifen or tamoxifen with estradiol that may have been estrogen-receptor mediated.

Animals↗

Luteinizing hormone releasing hormone, estrogen, and progesterone receptors in canine mammary lesions and tumor cell lines.

Nineteen canine mammary lesions were analyzed for estrogen receptor (ER), progesterone receptor (PR) and luteinizing hormone releasing hormone receptor (LHRHR) content. In addition, nine previously established canine mammary tumor cell lines with known ER and PR were analyzed for LHRHR. The incidence of receptors in the mammary tumor lesions was 21% for LHRHR, 10% for ER and 30% for PR. Statistical correlation was not observed between receptor status and diagnosis of malignant, benign, or hyperplastic lesions. A relationship between LHRHR and ER and PR content of canine mammary lesions or cell lines was not evident. The presence of functional hormone receptors offers opportunity for hormonal treatment of mammary cancer which may not be completely treatable by surgery. The observation of LHRHR in canine mammary tumors may offer therapeutic interventions other than surgery for mammary tumors unresponsive to antiestrogens.

Animals↗