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J C Woodrow

Publications and source records attributed to J C Woodrow.

At least 37 records · Page 2Linked to original sources
PubMed1986

The association of HLA-linked genes with systemic lupus erythematosus.

The reported associations between HLA antigen DR3 and null (QO) alleles at the C4A and C4B loci and systemic lupus erythematosus are here analysed. The empirical logistic method has been applied to a body of data which included the relevant genotypes. The analysis suggests that the association with null alleles at the C4 loci is primary and the DR3 association is likely to be secondary to this. This may give information as to the location of the HLA-linked disease susceptibility gene.

Alleles↗
PubMed1986

Ankylosing spondylitis, HLA-B27, and Klebsiella: a study of lymphocyte reactivity of anti-Klebsiella sera.

Twenty three anti-Klebsiella antisera were tested for their cytotoxic activity and four for their binding capacity for peripheral blood lymphocytes (PBL) from patients with HLA-B27 positive ankylosing spondylitis (AS+B27+) and from B27 positive (AS-B27+) and B27 negative (AS-B27-) healthy individuals. None of the antisera showed specific activity against PBL from any particular group. The antisera tested included two anti-Klebsiella K43 sera provided by an Australian group, who have reported them to be specifically cytotoxic for AS+B27+ PBL, four antisera raised against a Klebsiella K43 strain provided by this group, and an antiserum from another group, who have reported it as having increased binding capacity for AS+B27+ and AS-B27+ PBL compared with AS-B27- PBL. The results of other workers who have attempted to reproduce the results of either group are reviewed and the possible reasons for the repeated failure to confirm the reported findings are discussed.

Animals↗
PubMed1986

Analysis of the HLA association with rheumatoid arthritis.

Definitive determination of the HLA linked gene or genes for susceptibility to RA will be achieved (1) by the accumulation of an adequate body of data on the haplotype frequencies in a random set of RA patients and controls and (2) by further study of other loci in the DR region, involving the use of DNA probes as well as conventional techniques. Indirect evidence is here put forward to suggest that it may turn out that some part of DR4 specificity itself may be directly involved in increasing susceptibility and that DR1 epitopes may be involved in a similar way.

Arthritis, Rheumatoid↗
PubMed1985

HLA antigens in psoriasis and psoriatic arthritis.

HLA phenotypes were determined in 50 patients with psoriasis alone and in 50 patients with psoriasis and psoriatic arthritis. Positive associations were found in both groups with B13, B17, B37, Cw6, and DR7, and in addition with C4A6. Higher relative risks were found in respect to the patients with psoriasis alone compared with those with arthritis, and this suggests the involvement of additional genetic factors predisposing to peripheral arthritis. In patients with psoriasis only, the presence of Cw6 was associated with a significantly earlier age of onset.

Age Factors↗
PubMed1985

Genetic aspects of the spondyloarthropathies.

Family studies and investigation of the HLA associations have in recent years added to our understanding of the spondyloarthropathies. In regard to ankylosing spondylitis it is likely that B27 itself is the major susceptibility gene but that additional genes may play a secondary role. Heterogeneity of the B27 antigen has been demonstrated but has not yet been shown to be relevant to disease susceptibility. Haplotypes including Cw6 are related to susceptibility to psoriasis and psoriatic arthritis and although the risk for the arthropathy is increased in B27-positive individuals, there is some uncertainty regarding the association with other B locus antigens and further work is needed. There is also uncertainty as to whether B27-associated disorders occur randomly within families, or whether particular disorders cluster in certain families and further evidence in this field would be of considerable interest. Genetic studies, as here outlined, have not as yet had a major impact in clinical medicine but it is anticipated that a deeper understanding of the mechanisms of HLA-linked susceptibility genes and in particular of how they interact with environmental agents, will improve our ability to treat and possibly prevent the relevant diseases.

Adult↗
PubMed1985

Immunogenetic studies of recurrent spontaneous abortions in humans.

31 clinically defined couples suffering between 3 and 17 consecutive idiopathic spontaneous abortions have been studied. The female partners demonstrated a lower frequency than expected of serum lymphocytotoxic antibodies. Sharing of HLA-A, B or DR antigens was not significantly increased overall within these couples compared with controls, although two couples did show marked HLA sharing (greater than or equal to 4 antigens shared at HLA-A, B and DR loci). There was increased apparent HLA-A and HLA-B locus homozygosity in these women compared with controls (p less than 0.02 and p less than 0.005, respectively), with no significant apparent homozygosity either at HLA-DR or in the males. An increased prevalence of HLA-A, B and DR antigen phenotypes characteristic of various extended haplotypes was also observed in these couples.

Abortion, Habitual↗
PubMed1984

HLA-DR typing in coeliac disease: evidence for genetic heterogeneity.

Sixty nine propositi from a family study of coeliac disease were typed for HLA-DR antigens. Sixty three (91%) were found to carry the antigen DR3, which was a significantly greater proportion (p = 9.6 X 10(-24] than among the 168 controls (26%). Concurrently 42 children with the disease were DR typed. Not only was the frequency of DR3 significantly increased in these patients (86% versus 26% in controls; p = 3.1 X 10(-12] but so also was the frequency of DR7 (patients 60%, controls 29%; p = 5.8 X 10(-4]. When those propositi whose coeliac disease presented before the age of 20 were combined with the childhood coeliac group and a comparison made between these patients and the remainder of the propositi, all of whom presented when they were older than 20, the childhood onset group had a significant excess of DR7 (p = 2.2 X 10(-3] and a significant deficiency of DR2 (p = 3.5 X 10(-3]. These findings indicate that childhood coeliac disease and adult coeliac disease are genetically heterogeneous.

Adult↗
PubMed1983

Genetic studies in ankylosing spondylitis.

It is likely that ankylosing spondylitis is genetically heterogeneous. The evidence favours the gene for HLA-B27 being the major genetic factor responsible for susceptibility. The finding of a greater prevalence of disease in B27 positive first-degree male relatives of probands than in random B27 positive controls, suggests the existence of other genes for susceptibility, possibly HLA-linked.

Adult↗
PubMed1982

Are HLA antigens important in the development of alcohol-induced liver disease?

The prevalences of 10 HLA-A and 16 HLA-B antigens were determined in 50 patients with alcoholic cirrhosis and 120 alcoholic patients without cirrhosis and compared with those in a control group of 550 healthy subjects from the same geographical area. B40 was absent in the patients with cirrhosis but was found in 18 (15%) of the patients without cirrhosis (p = 0.0087). No other association was noted. It is concluded that there is no good evidence to date of an association between HLA antigen state and susceptibility to alcohol-induced cirrhosis.

ABO Blood-Group System↗
PubMed1981

DR antigens and rheumatoid arthritis: a study of two populations.

Thr prevalence of HLA-DR antigens was determined in a group of white patients with rheumatoid arthritis, similar patients originating from the Indian subcontinent, and corresponding controls. Rheumatoid arthritis was found to be highly associated with DR4 in the white patients but with DR1 in the Indian patients. These results raise the possibility that the DR antigens themselves do not play a part in increasing susceptibility to rheumatoid arthritis, but the locus for increased susceptibility is probably closely linked to the DR locus.

Arthritis, Rheumatoid↗