Search PubMed⌕ Search

Biomedical subjects

J C Weill

Publications and source records attributed to J C Weill.

45 records · Page 3Linked to original sources
PubMed1979

Bleomycin induces cataract formation in newborn rats in association with modifications of crystallin synthesis.

The antitumor antibiotic Bleomycin induces the formation of cataract when injected into newborn rats but not when injected into rats after 12 days or older. The development of these lesions is strictly associated with progressive biochemical modifications of the crystallins as demonstrated by electrophoresis on one and two-dimensional gels. When the lenses of the rats are observed histologically, the first modifications appear between 7 and 13 days after the injection of the drug concomitantly with the first biochemical modifications. Later on the fiber cells start to degenerate and there is a gradual destruction of the whole center of the lens.

Animals↗
PubMed1976

Intracellular modifications induced in mouse submaxillary glands by antibodies directed against saliva.

The purpose of this paper is to investigate whether an antibody directed against the exocrine secretion, saliva, is able to induce a modification in vivo within the specific cells of the submaxillary glands which synthesize this secretion. The salivary antigens synthesized within the glandular acinar cells are secreted into their respective lumen and are not present in the general circulation or in the intercellular spaces of the gland. When heterologous anti-saliva antibodies are injected into mice, they induce marked lesions within the acinar cells of the submaxillary glands. When different antibodies recognizing different salivary components are injected, they all induce similar modifications; it is not yet possible to distinguish whether different cells are involved in the synthesis of the different salivary components. The lesions described seem specific since other organs studied, such as the pancreas and the stomach, are unaffected. The different possible mechanisms of this cytotoxic effect are discussed.

Animals↗
PubMedDate not supplied

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice.

Immunoglobulin (Ig) and T-cell antigen receptor genes rearrange through identical heptamer-nonamer recognition sequences during entry of cells into the B or T lymphoid lineage. A similar enzymatic machinery may be used to perform these highly cell-specific events in these two types of lymphoid cells. We have investigated what the signal may be that triggers the rearrangement of one or other of the receptor genes in B or T cells. Mice from three transgenic lines carrying two, four or twenty copies of the unrearranged chicken lambda light-chain locus were analysed. In all three lines the chicken Ig transgene rearranges in B cells; in the line with 20 copies, a rearranged fragment can also be detected in thymus DNA. We conclude that the inserted chicken light-chain locus in its natural configuration contains target sequences that permit specific rearrangement in mouse lymphoid B cells, but that this precise differentiation step may be deregulated in thymic cells when the physiological level of relevant information is experimentally altered.

Animals↗