Biomedical subjects
J C Vij
Publications and source records attributed to J C Vij.
Controlled trial of levodopa in fulminant hepatitis.
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Effect of aging on the pancreatic ducts: a study based on endoscopic retrograde pancreatography.
Studies in the West have shown that with advancing age there is progressive atrophy and fibrosis of the pancreas. In addition, there is a gradual increase in diameter of the main pancreatic duct (MPD) with age. However, there is a discrepancy between the findings at autopsy and findings at endoscopic retrograde pancreatography (ERP). To examine this issue, ERP of subjects who were found not to show any abnormality of the biliary and pancreatic ducts were selected. They were divided by decade from 10 to 70 years and for statistical analysis into young (less than 40) and older (greater than or equal to 40) patients. There was no difference in length of the MPD between the two groups. However, the width of the MPD in the head was significantly greater in the older subjects (group 2; mean +/- SD = 3.78 +/- 0.97 mm) compared with those who were less than 40 years (group 1; 2.97 +/- 0.71 mm; p less than 0.001). Similarly, in the midbody the width of the MPD in group 2 (2.86 +/- 0.9 mm) was significantly greater compared with group 1 (2.36 +/- 0.51 mm; p less than 0.02). However, there was no difference in width of the MPD in the tail between the two groups. Length of the accessory pancreatic duct (APD) did not show any alteration with age but width was significantly greater in group 2 (1.94 +/- 0.69) compared with group 1 (1.49 +/- 0.51; p less than 0.05). No difference was observed in the length and width of the MPD or APD between male and female subjects of either group.(ABSTRACT TRUNCATED AT 250 WORDS)
Successful treatment of post-operative pleurobiliary fistula by endoscopic technique.
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Endoscopic balloon dilation of tuberculous duodenal strictures.
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Corrosive oesophageal strictures following acid ingestion: clinical profile and results of endoscopic dilatation.
There are several reports on oesophageal strictures caused by alkali ingestion, but information on oesophageal strictures due to acid ingestion is scarce. Endoscopic dilatation, which has been found to be quite safe and effective in the treatment of benign oesophageal strictures of other aetiology, has also not been evaluated adequately in the treatment of these strictures. Over a period of 2 years, of 47 patients treated at this centre of benign oesophageal strictures, 17 (36.2%) patients had strictures following ingestion of corrosive agents. Thirteen patients had ingested acids and only four gave a history of alkali ingestion. The age range of these 13 patients was 14-50 years (mean = 25.5 years, s.d. = 2.6). The amount of acid ingested varied from 10 to 100 ml (median = 50 ml). The interval between acid ingestion and presentation to hospital ranged from 1 to 60 months (median = 2 months). Ten patients had multiple strictures, and the most common site of involvement was the upper third followed by the lower third of the oesophagus. Only five of these 13 patients had evidence of gastric involvement in the form of antral stricture (four) and hour glass deformity (one). Strictures were dilated using Eder-Puestow metal olives passed over a guide wire. The total number of sittings required to achieve adequate dilatation in this group ranged from 1 to 30 (median = 14). Most patients were managed successfully with dilatation (good response 63.6%, satisfactory response 18.2%). On follow-up, recurrence of dysphagia was seen in a high number of patients (66%), but this could be managed easily with repeat dilatation.(ABSTRACT TRUNCATED AT 250 WORDS)
Severe acute pancreatitis due to hepatitis A virus infection in a patient of acute viral hepatitis.
The commonest causes of acute pancreatitis are cholelithiasis and alcohol. Rare causes include various viral infections, among which mumps is the commonest. Hepatitis A, hepatitis B and, recently, hepatitis E have been reported to cause acute but mild pancreatitis in patients with acute viral hepatitis. This report describes a case of severe acute pancreatitis caused by hepatitis A.
Changing epidemiology of acute hepatitis in a tertiary care hospital in Northern India.
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Salivary secretion in hypoproteinaemic states.
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Electrocardiographic changes during endoscopy.
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Budd Chiari syndrome in a child with hepatic tuberculosis.
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Nucleolar organiser regions in different colonic epithelia.
The argyrophilic technique (AgNOR) was applied to paraffin sections of 10 acute self-limited colitis, 15 ulcerative colitis (UC), 5 ulcerative colitis with indefinite dysplastic change, 10 adenomatous polyps, 20 colorectal adenocarcinomas and 10 normal colorectal mucosa. The mean number of nucleolar organiser regions (NORs) per nucleus ranged between 1.62-2.00 (95% CI 1.77-1.93) for normal colon, 2.47-3.80 (95% CI 2.71-3.21) for acute colitis, 1.66-2.75 (95% CI 2.13-2.44) for UC, 3.60-4.00 (95% CI 3.67-3.94) for UC with indefinite dysplasia, 3.00-4.04 (95% CI 3.41-3.81) for adenomatous polyps and 3.59-6.70 (95% CI 4.04-4.72) for colorectal adenocarcinoma. The differences observed were statistically significant. There was a significant difference of AgNOR counts between adenomatous polyp and UC with indefinite dysplasia in comparison to those observed in regenerative epithelium of acute colitis and UC without dysplasia. Hence the technique may be used as an adjunct to routine histology for delineating dysplastic changes in colonic epithelium.