Search PubMed⌕ Search

Biomedical subjects

J C Thompson

Publications and source records attributed to J C Thompson.

At least 505 records · Page 28Linked to original sources
PubMed1973

The role of thoracic duct lymph in gastrin transport and gastric secretion.

The effect of thoracic lymph diversion on gastric secretion has been studied in dogs. In addition, the concentration of gastrin in thoracic duct lymph of nine dogs and two patients has been measured before and during antral stimulation with either food or acetylcholine. The secretory studies do not support the concept that there is a significant gastric secretagogue in thoracic duct lymph. The amount of gastrin carried in thoracic duct lymph as determined by radioimmunoassay is far less than that necessary to evoke a gastric secretory response.

Acetylcholine↗
PubMed1973

Effect of nephrectomy on the rate and pattern of the disappearance of exogenous gastrin in dogs.

Studies of gastrin metabolism were performed in four dogs before and after nephrectomy. Synthetic human gastrin I was infused for two hours and serum samples were obtained at various times during and after infusion. Serum concentrations of gastrin were measured by radioimmunoassay. A two-compartment model was employed to calculate half-lives under each of four experimental conditions, low and high infusion rates, used both before and after nephrectomy. The model half-life was greatly prolonged after nephrectomy at both infusion rates (from 2.54 min to 5.15 min at the low rate, and from 2.85 min to 7.88 min at the high rate). The metabolic clearance rate, an expression of the rate of catabolism during infusion, decreased significantly after nephrectomy at both infusion rates. These observations indicate that the kidney is an important organ for the catabolism of exogenous gastrin.

Animals↗