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Biomedical subjects

J C Sutton

Publications and source records attributed to J C Sutton.

7 recordsLinked to original sources
PubMed1986

Chemonucleolysis. Current status and future outlook.

Chemonucleolysis is the most selective and least invasive technique available for the treatment of lumbar disc herniations which have failed to respond to conservative therapy. The technique of lateral discography is extremely exacting and should only be carried out by skilled surgeons who are highly trained in the management of lumbar disc disease. The risk of anaphylaxis following the injection of Chymopapain has been greatly reduced by premedicating patients with histamine I and histamine II receptor antagonists. Severe neurological complications are seen in 0.027% of cases treated. Factors contributing to this serious complication are discussed in detail. As with any surgical procedure patient selection is the most critical factor when classifying results following this form of therapy. When chemonucleolysis is reserved for patients who have sciatica as their major complaint, who demonstrate marked objective findings of nerve root compression, and have a posterolateral disc herniation confirmed by water soluble myelography or CAT scan, over 90% of these patients will be spared a surgical procedure.

Anesthesia↗
PubMed1986

Repeat chemonucleolysis.

A review of 33 patients in whom repeat chemonucleolysis was performed in the period between 1979 and 1983 indicates satisfactory results in 24 patients for a 73% success rate. Immediate sensitivity reactions (anaphylaxis) were seen in three patients and all were successfully managed by appropriate medical therapy. The last 12 patients were pretreated with histamine1 antagonists (hydroxyzine) and histamine2 antagonists (cimetidine). In this group there was not a single anaphylactic reaction. According to these results, repeat chemonucleolysis is a viable alternative to laminectomy and discectomy for patients suffering from recurrent lumbar disc herniations that are refractory to conservative therapy. The increased risk of sensitivity to the enzyme can be minimized by pretreatment with histamine blockers.

Adolescent↗
PubMed1986

Chemonucleolysis in the management of lumbar disc disease. A minimum six-year follow-up evaluation.

Of 208 chemonucleolysis procedures performed between April 1973 and June 1978, 189 (91%) were available for follow-up evaluation by comprehensive questionnaire after six to 11.2 years. Pain relief, activity level, and personal satisfaction are considered in patients otherwise eligible for discectomy. The procedures were done under general anesthesia with 18-gauge single needle technique using biplane image intensification and routine discography prior to Discase injection. Seventy-nine percent of patients were satisfied with their results, 85% males and 65% females. Sixty-two percent of workman's compensation patients and 57% of patients previously treated by laminectomy had a satisfactory result. Ninety-five percent of patients had disc space narrowing postoperatively. Complications were few and of no lasting concern. Of the failures, 12.7% had laminectomies within 18 months of injection while 9.5% had a satisfactory result for at least two years. Disc reexpansion was demonstrated after postinjection narrowing in 14% of 58 cases roentgenographically evaluated, including patients of the 2nd, 3rd, and 4th decade of life. Recurrence rate in the total series was 9.5%. Chemonucleolysis is the least traumatic invasive procedure capable of removing the nucleus pulposus and is most effective when used in the treatment of lumbar disc herniation with objective signs of nerve root compression. In this series, approximately 80% of patients were spared open surgery.

Activities of Daily Living↗
PubMed1978

Direct observation of fungal aggregates in sand dune soil.

The mycorrhizal fungus Glomerus in association with bean hosts, Phaseolus vulgaris L., growing in pot cultures and grass hosts, Calamovilfa longiflora (Hook). Scribn and Andropogon sp. growing on Lake Huron sand dunes produced extensive external mycelium. This mycelium was the dominant factor in the aggregation of soil particles. Light and scanning electron microscope studies indicated that the sand grains were attached to the hyphae. An amorphous deposit was often present at the interfaces of sand grains and hyphae. It appeared to act as an adhesive. Staining procedures indicated that this material contained polysaccharide. Other microogranisms were observed in association with the Glomus hyphae and the amorphous deposits.

Bacteria↗
PubMed1975

Man's physiologic response to long-term work during thermal and pollutant stress.

Metabolic, temperature, and cardiorespiratory responses of 19 healthy males, age range 18-30 yr for one group and 40-55 yr for another, were studied during 210 minutes submaximal work at 35% Vo2 max. The subjects were exposed to four different pollutant gas mixtures at two different temperatures, 25 degrees C and 35 degrees C (relative humidity 30%). The four gas mixtures were filtered air (FA), 50 ppm carbon monoxide in filtered air (CO), 0.24 ppm peroxyacetyl nitrate in filtered air (PAN), and a combination of all three mixtures (PANCO). In the CO exposure, the heart rate was significantly greater than that observed during FA conditions (P less than 0.05). Metabolic and thermoregulatory responses to long-term work were not different in the various pollutant environments. Significant decreases in stroke volume and increases in heart rate were observed during the course of the 25 degrees C exposures with no alteration in cardiac output. Heart rates were higher during 35 degrees C exposures while cardiac output remained at the same level with a consequent further reduction in stroke output.

Adolescent↗