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Biomedical subjects

J C Stuart

Publications and source records attributed to J C Stuart.

35 records · Page 2Linked to original sources
PubMed1981

Endothelial morphology in long-term keratoconus corneal transplants.

Endothelial morphology was studied in 55 long-term keratoconus grafts. Photographs were taken with a Zeiss non-contact endothelial lens and analyzed with a Zeiss MOP-3 digital analyzer. Donor ages were known in 39 cases. Statistical analysis was carried out correlating endothelial cell count with several parameters, including recipient age and cell form as expressed by the coefficient of variation. Cell counts varied from 502 to 1708 cells/mm2. No correlation between cell counts and donor age was found. Recipient age had an unexpected significance as a predictor of endothelial cell survival in that cell counts decreased as recipient age increased despite donor age. As the grafts aged, more cell pleomorphism was found as expressed by the coefficient of variation.

Adolescent↗
PubMed1980

The federal response to drug abuse: 1976-1980.

Drug use remains a prominent aspect of the American environment. Consequently, this analysis was undertaken to examine the current as well as the projected role of the federal government in drug abuse. Based on an examination of federal expenditures between the years of 1976 and 1980, the intelligence, corrections, interdictions, federal prosecutions, and compliance categories have increased their proportions of the budget, but not enough to compensate for inflation. Based on the foregoing, there is a continuing desire for states to increase their operational responsibilities; however, a well-structured mechanism for evaluation in law enforcement efforts is lacking. Even so, it appears that the level of concern accorded by the federal government to psychoactive substance use is progressively decreasing.

Budgets↗
PubMed1978

An outbreak of monensin poisoning in adult turkeys.

Monensin, fed in excess of 200 ppm caused mortality in Triple 5 and Triple 6 turkeys aged 25 weeks old and over. Mortality commenced three to four days after administering feed containing monensin and ceased three to five days after it was removed. This concentration of drug did not have any detectable adverse effects on Triple 5 turkeys fed from day old, four weeks old, or 11 weeks old for periods of two weeks.

Animal Feed↗
PubMed1975

Ultrastructural variation in granular dystrophy of the cornea.

Corneal deposits of granular dystrophy were studies in six corneas from five patients. Two additional corneas from two patients with lattice dystrophy were used for comparison. The diagnoses were confirmed by light and electron microscopy. Three types of ultrastructural features were distinguished in the electron-dense rod-shaped deposits of granular dystrophy, i.e., Type 1 with homogenous structure, Type 2 with fibrillar constituents, and Type 3 with a moth-eaten or sponge-like appearance. In polarization microscopy of Congo-red stained sections, the Type 2 tended to show an increased birefringence without green dichroism, while the other types were less birefringent than the stroma. Three different components were found immediately around the deposits, i.e., 1. normal collagen fibrils, 2. finely filamentous substance, and 3. areas of thin fibrils (70-100 A in diameter). While the second component appeared non-specific, the third component was found only in two corneas, superimposed on the lesions of granular dystrophy, and showed light and electron microscopic characteristics of the lesions of amyloid as well as of lattice dystrophy.

Aged↗
PubMed1975

Recurrent granular corneal dystrophy.

Four full-thickness corneal buttons and tissue from one lamellar keratoplasty, derived from four patients with granular corneal dystrophy recurring in previously transplanted corneas, were studied by light and transmission electron microscopy. Fibrous tissue without vascularization was present between the epithelium and Bowman's membrane and contained deposits characteristic of granular dystrophy in both light and electron microscopy. The recurrence of dystrophy in the normal donor cornea is the result of infiltration of the grafted cornea by host invasion. The donor stroma is spared.

Adolescent↗
PubMedDate not supplied

Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species.

The cardiotonic activity of milrinone (Win 47203), a potent analogue of amrinone, was demonstrated in isolated guinea pig, cat, rabbit, rat, and hamster atria and papillary muscles. Milrinone, in concentrations of 0.1-300 micrograms/ml, caused concentration-dependent increases in guinea pig papillary muscle and atrial developed tension with minimal increases in atrial rate. Compared with the in vitro inotropic activity of amrinone, milrinone was approximately 30 times more potent. The inotropic and chronotropic effects of milrinone do not appear to be mediated by the release of endogenous norepinephrine, by the direct stimulation of beta-adrenergic or histaminergic receptors, or through the stimulation of prostaglandin synthesis. The inotropic response of the guinea pig papillary muscles to isoproterenol was potentiated when isoproterenol was given at the peak effect of a minimally effective concentration of milrinone or after prolonged incubation with milrinone. No potentiation was observed when isoproterenol was administered at the peak effect of a high concentration of milrinone, which suggests that the positive inotropic action of milrinone may not be solely attributable to cyclic AMP phosphodiesterase inhibition.

Aminopyridines↗
PubMedDate not supplied

Candida albicans transmission by penetrating keratoplasty.

Transmission by microbial infection from donor to host during penetrating keratoplasty is of continuing concern to corneal transplant surgeons. Eye banks routinely use antibiotic and/or antiseptic solutions to pretreat donor eyes used for transplantation, but specific antifungal agents are not given. We report a case of Candida albicans endophthalmitis that occurred after using a donor eye found to have Candida positive cultures.

Aged↗