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Biomedical subjects

J C Shastry

Publications and source records attributed to J C Shastry.

At least 73 records · Page 4Linked to original sources
PubMed1984

The pattern of medical renal disease in children in a south Indian hospital.

A retrospective study of children admitted to a south Indian hospital during an 11 year period showed that 70% of the renal diseases encountered in children in this region are of types which have a good prognosis. Post-streptococcal glomerulonephritis was the most common. The relative prevalence of steroid-sensitive nephrotic syndrome and different histological types of idiopathic nephrotic syndrome was similar to that in developed Western countries. Haemolytic-uraemic syndrome complicating bacillary dysentery was the most common cause of acute renal failure.

Acute Kidney Injury↗
PubMed1983

Streptococcal antibodies and complement components in tropical post-streptococcal glomerulonephritis.

Anti-deoxyribonuclease "B' was elevated in 94.9% of 59 cases of post-streptococcal glomerulonephritis studied, whereas ASO was elevated only in 54.4% of cases showing that the ADNB titre is a more sensitive indicator of antecedent streptococcal infection than ASO, in tropical countries with a high prevalence of pyoderma. Serum C3c (beta 1A) levels were significantly decreased, especially in the early phase of the illness and returned to normal with remission. C4 levels were decreased only in the early phase of the illness, suggesting involvement of the alternate pathway subsequent to classical pathway activation.

Adolescent↗
PubMed1983

Membranoproliferative glomerulonephritis in a tropical environment.

Electron microscopy of renal biopsy material from 50 patients with membranoproliferative glomerulonephritis treated in a southern Indian hospital, showed a low prevalence of type 2 (dense deposit) disease. Eosinophilia was seen in more than one-third of the 41 patients with type 1 disease. Associated diseases and possible sources of chronic antigenaemia found in some patients included: streptococcal infection, Bancroftian filariasis, tropical pulmonary eosinophilia, hepatitis B surface antigenaemia and lepromatous leprosy.

Adolescent↗
PubMed1982

Renal ultrastructure in acute tubular necrosis following Russell's viper envenomation.

Electron microscopic examination of renal biopsies from nine patients who developed renal failure after Russell's viper bite showed glomerular mesangial hypercellularity, vascular endothelial swelling, tubular epithelial necrosis and shedding, acellular segments of tubular basement membrane and an interstitial infiltrate composed of mast cells, eosinophils, lymphocytes and plasma cells. These cells showed many close contacts with each other and with fibroblasts. Severe vascular and tubular lesions were also present in the medulla. These abnormalities and other reported clinical and laboratory investigations in this condition, suggest that the primary lesion is a reversible intravascular coagulation with secondary ischaemic tubular damage. The inflammatory response in the interstitium is probably initiated by a release of antigens from damaged tubules.

Acute Kidney Injury↗
PubMed1982

Outcome of the haemolytic-uraemic syndrome complicating bacillary dysentery.

Seventy-eight children were treated for the haemolytic-uraemic syndrome complicating bacillary dysentery over a ten-year period. Early dialysis favoured survival significantly. The renal status of 22 of the 28 survivors was re-evaluated 18-84 months after initial hospitalization. Complete recovery was found in all except two patients; one of them had neurological sequelae and the other a glomerulonephritic disease.

Child↗
PubMed1982

Thioflavin T fluorescence in membranoproliferative glomerulonephritis.

Paraffin-embedded renal biopsy material from 50 cases of membranoproliferative glomerulonephritis (MPGN) was studied by thioflavin T staining and electron microscopy. Glomerular capillaries showed bright diffuse linear thioflavin T fluorescence in all cases of MPGN type 2 and also in some cases of MPGN types 1 and 3. This pattern of fluorescence appears to be related to the extent of intraglomerular deposits, rather than their location or nature.

Benzothiazoles↗
PubMed1982

Terminal infections in renal transplant patients in a tropical environment.

Infections were a major cause of death in 84% of 38 autopsied renal allograft recipients in a south Indian hospital. Pyogenic bacteria and fungi were the most common etiological agents encountered, being present in 50 and 47% of cases, respectively. Tuberculosis and hepatitis B virus infection were more prevalent and Pneumocystis carinii and cytomegalovirus disease rarer than in comparable series from non-tropical countries. 1 case each of amoebiasis, strongyloidiasis and filariasis were the parasitic infections encountered.

Adult↗
PubMed1982

Renal transplantation in leprosy.

A patient with tuberculoid leprosy and chronic renal failure was given a renal allograft after 5 months of dapsone (DDS) treatment. The leprosy showed continued healing in spite of immunosuppression and was not a significant cause of morbidity. Tuberculoid leprosy does not appear to be a contraindication for renal transplantation.

Adult↗
PubMed1981

Nephron injury in the haemolytic-uraemic syndrome complicating bacillary dysentery.

The electron microscopic appearances of renal biopsy material from four children who developed the haemolytic-uraemic syndrome as a complication of bacillary dysentery are described. Glomerular lesions present included deposits of fibrin and platelets, subendothelial rarefaction and lysis of endocapillary cells with or without necrosis of glomerular epithelial cells and periglomerular tissue. Tubular epithelial necrosis and cytoplasmic degeneration with an infiltrate of lymphocytes and plasma cells were also seen. It is likely that the different glomerular lesions result from thrombosis and obstruction of blood vessels at various levels of the intrarenal circulation. The tubulo-interstitial changes appear to be secondary to glomerular lesions.

Child, Preschool↗
PubMed1981

Abnormalities of the immune system in patients with chyluria.

A study of the immune system in 11 patients with chyluria showed lymphocytopenia, decrease in T cells, a low serum IgA concentration and suppression of delayed hypersensitivity responses to intradermally injected antigens. The similarity of chyluria to intestinal lymphangiectasia and thoracic duct fistula suggests that the immune deficiency may be due to loss of lymph in the urine.

Adult↗
PubMed1981

Renal ultrastructure in cortical necrosis following Russell's viper envenomation.

Electron microscopic examination of biopsy material from two patients with renal cortical necrosis following Russell's viper bite, showed extensive destruction of glomerular and tubular cells with haemorrhage into the glomerular urinary space and tubules. The non-selective cell destruction seen suggests an ischaemic aetiology and the presence of fibrin in the glomeruli indicates that the ischaemia may be due to intravascular coagulation.

Adult↗